Ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate

Base Information

• Chemical Name: Ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate
• CAS No.: 6940-07-4
• Molecular Formula: C20H19NO4
• Molecular Weight: 337.3692
• NSC Number: 25359
• DSSTox Substance ID: DTXSID00282288

Synonyms:6940-07-4;ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate;NSC25359;DTXSID00282288;NSC-25359

Chemical Property of Ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate

Chemical Property:

• Vapor Pressure: 1.92E-09mmHg at 25°C
• Boiling Point: 481.9°Cat760mmHg
• Flash Point: 245.2°C
• Density: 1.25g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 337.13140809
• Heavy Atom Count: 25
• Complexity: 530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(C(=O)N(C1C2=CC=CC=C2)C3=CC=CC=C3)OC

Technology Process of Ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate

There total 3 articles about Ethyl 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-1h-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate (61429-66-1) → 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-pyrrole-3-carboxylic acid ethyl ester (6940-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrosulfite / H₂O; dioxane / 0.5 h / Ambient temperature

2: CH₂Cl₂; diethyl ether

With sodium disulfite; In 1,4-dioxane; diethyl ether; dichloromethane; water;

DOI:10.3987/COM-93-6479

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + ethyl 4?hydroxy?5?oxo?1,2?diphenyl?2,5?dihydro?1H?pyrrole?3?carboxylate (131189-25-8) → 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-pyrrole-3-carboxylic acid ethyl ester (6940-07-4)

Guidance literature:

In diethyl ether; dichloromethane; Yield given;

DOI:10.3987/COM-93-6479

Reference yield:

→ 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-pyrrole-3-carboxylic acid ethyl ester (6940-07-4)

Guidance literature:

/BRN= 291646/;

DOI:10.1021/ja01175a083

upstream raw materials:

diazomethane

ethyl 4?hydroxy?5?oxo?1,2?diphenyl?2,5?dihydro?1H?pyrrole?3?carboxylate

ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate

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