131189-25-8

Upstream product

• 61429-66-1 ethyl 4,5-dioxo-1,2-diphenyl-4,5-dihydro-1H-pyrrole-3-carboxylate 
• 996-82-7 sodium diethylmalonate 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 538-51-2 benzylidene phenylamine 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 108-56-5 diethyl oxaloacetate 

Downstream Products

• 131189-42-9 1,5-Diphenyl-3-(9-fluorenyloxy)-4-ethoxycarbonyl-2,5-dihydropyrrol-2-one 
• 131189-29-2 4-Benzhydryloxy-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131189-40-7 1,5-Diphenyl-3-benzyloxy-4-ethoxycarbonyl-2,5-dihydropyrrol-2-one 
• 6940-07-4 4-methoxy-5-oxo-1,2-diphenyl-2,5-dihydro-pyrrole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Efficient Synthesis of 3-Pyrrolin-2-one Derivatives in Aqueous Media

An efficient one-pot, three-component synthesis of 3-pyrrolin-2-ones in aqueous media at room temperature is reported. This reaction provides a green and catalyst-free method for generation of 3-pyrrolin-2-one derivatives in good yields.

In-water facile synthesis of poly-substituted 6-arylamino pyridines and 2-pyrrolidone derivatives using tetragonal nano-ZrO2 as reusable catalyst

Here, we report a facile synthetic protocol to access a series of ethyl 5-cyano-2-methyl-4-aryl-6-(arylamino)nicotinates and ethyl 4-hydroxy-2-(4-nitroaryl)-5-oxo-1-aryl-2,5-dihydro-1H-pyrrole-3-carboxylates using tetragonal nano-ZrO2 as reusab

Visible light-promoted synthesis of pyrrolidinone derivatives via Rose Bengal as a photoredox catalyst and their photophysical studies

Herein, we report an intramolecular radical cyclization reaction towards the synthesis of pyrrolidinone derivatives via metal-free photoredox catalysis under irradiation from blue LEDs. Some of the remarkable features of this protocol include synthetic ef

Malic acid as an effective and valuable bioorganocatalyst for one-pot, three-component synthesis of pyrrolidinone derivatives

Malic acid was used as an effective and valuable bioorganocatalyst for the one-pot, three-component synthesis of important and noteworthy pyrrolidinone derivatives in green solvent at 50oC. Ecofriendly, simplicity in operation, cleaner reaction profile, s

Anti-pathogenic properties of the combination of a t3ss inhibitory halogenated pyrrolidone with c-30 furanone

Antimicrobial resistance is one of the current public health challenges to be solved. The World Health Organization (WHO) has urgently called for the development of strategies to expand the increasingly limited antimicrobial arsenal. The development of an

Green one-pot multicomponent synthesis of pyrrolidinones using planetary ball milling process under solvent-free conditions

This paper presents a novel and efficient protocol for the synthesis of pyrrolidinones using catalytic loading of 1,1'-butylenebis(3-sulfo-3H-imidazol-1-ium) hydrogen sulfate as a recyclable Br?nsted acid ionic liquid through ball milling process at room temperature under solvent-free conditions. The developed method provides good to excellent yields of various pyrrolidinones in environmentally friendly conditions. Furthermore, this efficient protocol displays a combination of the synthetic advantage of one-pot multicomponent reaction with ecological benefits and convenience of a mechanochemical procedure.

Magnetic cobalt ferrite nanoparticles functionalized with citric acid as a green nanocatalyst for one-pot three-component sonochemical synthesis of substituted 3-pyrrolin-2-ones

Abstract: A clean, convenient and facile approach for one-pot ultrasonic assisted synthesis of substituted 3-pyrrolin-2-ones from diethyl acetylenedicarboxylate, aniline and aldehyde derivatives is described. The reactions were carried out in the presence

An Efficient Synthesis of Pyrrolidinone Derivatives in the Presence of 1,1′-Butylenebis(3-sulfo-3 H -imidazol-1-ium) Chloride

The catalytic efficiency of 1,1′-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid-functionalized ionic liquid was demonstrated for the synthesis of pyrrolidinone derivatives under mild conditions. The electronic effect of substituents on aniline derivatives was investigated. Further, a study on the structure-activity relationship of ionic liquids containing sulfonic groups for the synthesis of ethyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate was performed under optimal conditions. The results showed that the catalytic properties of ionic liquids containing two sulfonic or imidazole moieties with carbon spacers was superior to ionic liquids having one sulfonic or imidazole moiety with no carbon spacer.

Synthesis of pyrrolidinone derivatives from aniline, an aldehyde and diethyl acetylenedicarboxylate in an ethanolic citric acid solution under ultrasound irradiation

The ultrasound-promoted one-pot multicomponent synthesis of substituted 3-pyrrolin-2-ones using citric acid as a green additive in a green solvent is reported. Citric acid catalyzed the reaction efficiently without the need for any other harmful organic r

Admicellar catalysis in multicomponent synthesis of polysubstituted pyrrolidinones

A multicomponent green methodology was developed to synthesize 3-hydroxy-2-pyrrolidinones under admicellar catalysis by TiO2 nano-particles at room temperature (30 C). TiO2 nano-particles in aqueous CTAB solution promote the formation of admicelles and the reaction occurs in admicellar environment. The methodology was successfully applied to synthesize a variety of 3-hydroxy-2-pyrrolidinones and 3′-hydroxyspiro- 2′-pyrrolidinone derivatives.