2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione
• CAS No.: 19357-30-3
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• DSSTox Substance ID: DTXSID60356590
• Wikidata: Q82136025
• Mol file: 19357-30-3.mol

Synonyms:19357-30-3;2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione;2-(2,4-dimethylphenyl)isoindole-1,3-dione;2-(2,4-Dimethylphenyl)isoindoline-1,3-dione;STK247418;Oprea1_301102;Oprea1_510971;DTXSID60356590;AKOS000734503;NCGC00186530-01;N-(2,4-dimethylphenyl)isoindoline-1,3-dione;SR-01000317919;SR-01000317919-1;2-(2,4-dimethylphenyl)-2,3-dihydro-1H-isoindole-1,3-dione

Chemical Property of 2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 368

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N2C(=O)C3=CC=CC=C3C2=O)C

Technology Process of 2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione

There total 12 articles about 2-(2,4-dimethylphenyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

phthalic anhydride (85-44-9) + 2,4-Xylidine (95-68-1) → N-(2,4-dimethylphenyl)isoindoline-1,3-dione (19357-30-3)

Guidance literature:

With o-phthalimide-N-sulfonic acid; In ethanol; at 80 ℃; for 3h; Green chemistry;

DOI:10.1007/s11696-017-0223-7

Reference yield: 19.0%

phthalimide (136918-14-4,85-41-6) + tris(2,4-dimethylphenyl)bismuth diacetate → N-(2,4-dimethylphenyl)isoindoline-1,3-dione (19357-30-3)

Guidance literature:

With copper diacetate; In tetrahydrofuran; pyridine; for 72h; Ambient temperature;

DOI:10.1016/S0040-4020(98)01185-5

Reference yield:

phthalimide (136918-14-4,85-41-6) + m-xylene (108-38-3,104809-90-7) → 2-(3,5-dimethylphenyl)isoindoline-1,3-dione (40101-45-9) + N-(2,4-dimethylphenyl)isoindoline-1,3-dione (19357-30-3) + N-(2,6-dimethylphenyl)phthalimide (20730-99-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 145 ℃; for 3h; Microwave irradiation;

DOI:10.1021/ja2087085

upstream raw materials:

phthalic anhydride

2,4-Xylidine

N,N'-bis-(2,4-dimethyl-phenyl)-phthalamide

Phthaloyl dichloride

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