{[(6-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)

Base Information

• Chemical Name: {[(6-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)
• CAS No.: 70010-79-6
• Molecular Formula: C₇H₁₂N₂O₆P₂
• Molecular Weight: 282.13
• Mol file: 70010-79-6.mol

Synonyms:Phosphonicacid, [[(6-methyl-2-pyridinyl)amino]methylene]bis- (9CI); [[(6-Methyl-2-pyridinyl)amino]methylene]bisphosphonicacid

Chemical Property of {[(6-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)

Chemical Property:

• Vapor Pressure: 2.22E-19mmHg at 25°C
• Boiling Point: 679.3°Cat760mmHg
• Flash Point: 364.6°C
• Density: 1.796g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of {[(6-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)

There total 4 articles about {[(6-methylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tetra(trimethylsilyl) (6-methylpyridin-2-ylamino)methylenebisphosphonate → [[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisphosphonate (70010-79-6)

Guidance literature:

With methanol; In diethyl ether; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.jorganchem.2020.121177

Reference yield:

tetraethyl [(6-methylpyridin-2-ylamino)methylene]bis(phosphonate) → [[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisphosphonate (70010-79-6)

Guidance literature:

With hydrogenchloride; at 120 ℃;

DOI:10.1021/jm030084x

Reference yield:

N-(6-methylpyridin-2-yl)formamide (38614-78-7) → [[(6-methyl-2-pyridinyl)amino]methylene]-1,1-bisphosphonate (70010-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 Torr / Inert atmosphere; Heating

2: methanol / diethyl ether / 20 °C / Inert atmosphere

With methanol; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane;

DOI:10.1016/j.jorganchem.2020.121177

upstream raw materials:

N-(6-methylpyridin-2-yl)formamide

2-Amino-6-methylpyridine