Levobupivacaine

Base Information

Chemical Name:Levobupivacaine
CAS No.:27262-47-1
Molecular Formula:C18H28N2O
Molecular Weight:288.433
Hs Code.:2933399090
European Community (EC) Number:690-076-7
UNII:A5H73K9U3W
DSSTox Substance ID:DTXSID8048496
Nikkaji Number:J153.469F
Wikipedia:Levobupivacaine
Wikidata:Q3272027
NCI Thesaurus Code:C87594
Pharos Ligand ID:1K8VDFWQQMK8
Metabolomics Workbench ID:43248
ChEMBL ID:CHEMBL1201193
Mol file:27262-47-1.mol

Synonyms:Chirocaine;levobupivacaine;levobupivacaine hydrochloride

Suppliers and Price of Levobupivacaine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(-)-Bupivacaine
25mg
$ 95.00

Crysdot
(S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide 95+%
1g
$ 849.00

Chemenu
(S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide 95%
1g
$ 794.00

Biosynth Carbosynth
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide
10 g
$ 160.00

Biosynth Carbosynth
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide
50 mg
$ 400.00

Biosynth Carbosynth
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide
25 mg
$ 290.00

Biosynth Carbosynth
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide
5 mg
$ 100.00

Biosynth Carbosynth
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide
2 mg
$ 56.00

AvaChem
Levobupivacaine
10g
$ 475.00

AvaChem
Levobupivacaine
1g
$ 95.00

Total 75 raw suppliers

Chemical Property of Levobupivacaine

Chemical Property:

Melting Point:254ºC (dec.)(lit.)
Refractive Index:1.5700 (estimate)
Boiling Point:423.4 °C at 760 mmHg
PKA:14.85±0.70(Predicted)
Flash Point:209.9 °C
PSA：32.34000
Density:1.032 g/cm³
LogP:4.70940
Storage Temp.:Refrigerator
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:288.220163521
Heavy Atom Count:21
Complexity:321

Purity/Quality:

99% ^*data from raw suppliers

(S)-(-)-Bupivacaine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,T+
Hazard Codes:Xn,T+

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Isomeric SMILES:CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C
Recent ClinicalTrials:Safety and Efficacy of Magnesium Sulphate as an Adjuvant to Levobupivacaine in Ultra-sound Guided Transversus Abdominis Plan Block in Pediatric Abdominal Cancer Surgery
Recent EU Clinical Trials:PAIN CONTROL WITH THE USE OF WALANT IN TOTAL TRAPEZECTOMY. RANDOMIZED CLINICAL TRIAL
Recent NIPH Clinical Trials:The analgesic efficacy of constant fentanyl infusion and IV acetaminophen with transversus abdominis plane block in thoracoscopic esophagectomy: a randomized controlled trial.
Uses Local anaesthetic used for epidural and intrathecal anaesthesia.
Therapeutic Function Local anesthetic

Technology Process of Levobupivacaine

There total 41 articles about Levobupivacaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 27262-45-9
(+)-Bupivacaine

: 14252-80-3,2180-92-9,27262-45-9,27262-47-1,38396-39-3
racemic bupivacaine

Guidance literature:: With water; In ethylene glycol; at 138 ℃; for 9h;

Reference yield: 95.0%

: 109-65-9
1-bromo-butane

: 27262-40-4
(S)-2',6'-pipecoloxylidide

: 27262-47-1
levobupivacaine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield: 94.8%

: 67-66-3,8013-54-5
chloroform

: C₉H₁₈ClN

: 87-62-7
2,6-dimethylaniline

: 27262-47-1
levobupivacaine

Guidance literature:: With [2,2]bipyridinyl; cesiumhydroxide monohydrate; copper diacetate; potassium carbonate; In toluene; at 100 - 105 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;