(25R)-2β,3β-Dihydroxy-5β-spirostan-12-one

Base Information

• Chemical Name: (25R)-2β,3β-Dihydroxy-5β-spirostan-12-one
• CAS No.: 16680-64-1
• Molecular Formula: C₂₇H₄₂O₅
• Molecular Weight: 446.627
• Mol file: 16680-64-1.mol

Synonyms:5b-Spirostan-12-one, 2b,3b-dihydroxy-, (25R)- (8CI); Mexogenin (6CI);Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirostan-12-onederiv.; 2b,3b-Dihydroxy-5b,25D-spirostan-12-one

Chemical Property of (25R)-2β,3β-Dihydroxy-5β-spirostan-12-one

Chemical Property:

• Melting Point: 246 °C
• Boiling Point: 566.7±50.0 °C(Predicted)
• PKA: 14.59±0.70(Predicted)
• PSA: 75.99000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 3.94360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (25R)-2β,3β-Dihydroxy-5β-spirostan-12-one

There total 13 articles about (25R)-2β,3β-Dihydroxy-5β-spirostan-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Di-O-acetyl-neomanogenin (16653-67-1,137853-56-6) → Neomanogenin (564-43-2,16680-64-1,60433-70-7,122330-88-5,122331-52-6)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01202a036

Reference yield:

(25R)-5α-spirost-2-en-12-one (60433-69-4) → (25R)-2α,3α-dihydroxy-5α-spirostan-12-one (564-43-2,16680-64-1,60433-70-7,122330-88-5,122331-52-6)

Guidance literature:

With pyridine; osmium(VIII) oxide; benzene; Erwaermen des Reaktionsprodukts mit Natriumsulfit und Natriumsulfat in wss. Methanol und Benzol;

DOI:10.1021/ja01596a054

Reference yield:

(25R)-2α,3β,26-triacetoxy-5α-furost-20(22)-en-12-one → cyclopseudomanogenin (564-43-2,16680-64-1,60433-70-7,122330-88-5,122331-52-6)

Guidance literature:

With potassium hydroxide; anschliessendes Behandeln mit Essigsaeure;

DOI:10.1021/ja01626a058

upstream raw materials:

(25R)-5α-spirost-2-en-12-one

pyridine

benzene

Di-O-acetyl-neomanogenin

Downstream raw materials:

manogenin

Refernces