(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid

Base Information

Chemical Name:(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid
CAS No.:193885-60-8
Molecular Formula:C31H43NO4
Molecular Weight:493.67700
Hs Code.:
DSSTox Substance ID:DTXSID20514179
Nikkaji Number:J1.803.746G
Wikidata:Q82374354
Mol file:193885-60-8.mol

Synonyms:193885-60-8;(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexadecanoic acid;DTXSID20514179;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexadecanoic acid

Suppliers and Price of (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid

Chemical Property:

PSA：79.12000
LogP:8.27390
XLogP3:9.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:18
Exact Mass:493.31920885
Heavy Atom Count:36
Complexity:616

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCCCCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES:CCCCCCCCCCCCCC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid

There total 5 articles about (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)hexadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 478706-48-8
tert-butyl L-2-[(9-fluorenylmethoxycarbonyl)amino]hexadecanoate

: 193885-60-8
Fmoc-L-tetradecyl glycine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1002/1099-0690(200208)2002:16<2736::AID-EJOC2736>3.0.CO;2-5

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 193885-60-8
Fmoc-L-tetradecyl glycine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NaOH / dioxane; H₂O / 40 °C / pH 8 - 9

2: 98 percent / TFA / CH₂Cl₂ / 1.5 h / 20 °C

With sodium hydroxide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/1099-0690(200208)2002:16<2736::AID-EJOC2736>3.0.CO;2-5

Reference yield:

: 478706-42-2
tert-butyl(2S)-2-{[(1R,2R,5R)-2-hydroxy-2,6,6-trimethylbicyclo-[3.1.1]hept-3-ylidene]amino}hexadecanoate

: 193885-60-8
Fmoc-L-tetradecyl glycine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NH₂OH*HCl / methanol / 20 °C

2: 83 percent / NaOH / dioxane; H₂O / 40 °C / pH 8 - 9

3: 98 percent / TFA / CH₂Cl₂ / 1.5 h / 20 °C

With sodium hydroxide; hydroxylamine hydrochloride; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1002/1099-0690(200208)2002:16<2736::AID-EJOC2736>3.0.CO;2-5