1-Ethyl-3-hydroxypiperidine

Base Information

• Chemical Name: 1-Ethyl-3-hydroxypiperidine
• CAS No.: 13444-24-1
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 29333999
• European Community (EC) Number: 236-584-0
• UNII: 3T4EP179I2
• DSSTox Substance ID: DTXSID00871217
• Nikkaji Number: J4.547K
• Wikidata: Q27257998
• Mol file: 13444-24-1.mol

Synonyms:1-Ethyl-3-hydroxypiperidine;13444-24-1;1-Ethylpiperidin-3-ol;1-Ethyl-3-piperidinol;N-Ethyl-3-piperidinol;3-Piperidinol, 1-ethyl-;N-Ethyl-3-hydroxypiperidine;3-Hydroxy-1-ethylpiperidine;UNII-3T4EP179I2;3T4EP179I2;EINECS 236-584-0;AI3-27593;N-Ethyl-3-hydroxy piperidine;Ethyl-3-hydroxypiperidine;3-hydroxy-n-ethylpiperidine;Dactilake;1-ethyl-piperidin-3-ol;n-ethyl-3-hydroxypiperidin;SCHEMBL214553;DTXSID00871217;1-ETHYL-3-PIPERIDINOL [MI];MFCD00006508;AKOS000120287;SB41094;AC-15325;AS-40732;AM20080247;CS-0075008;E0376;FT-0607746;A806781;W-108285;Q27257998;F0001-0453;Z104478102

Chemical Property of 1-Ethyl-3-hydroxypiperidine

Chemical Property:

• Appearance/Colour: clear viscous liquid
• Vapor Pressure: 0.149mmHg at 25°C
• Melting Point: <25 °C
• Refractive Index: n20/D 1.477(lit.)
• Boiling Point: 190.12 °C at 760 mmHg
• PKA: 14.83±0.20(Predicted)
• Flash Point: 47.222 °C
• PSA: 23.47000
• Density: 0.978 g/cm³
• LogP: 0.40090
• Storage Temp.: Flammables area
• Water Solubility.: 791.3g/L at 25℃
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

99.9% ^*data from raw suppliers

1-Ethyl-3-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn,Xi
• Statements: 22-38-36/37/38-10
• Safety Statements: 23-28-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCCC(C1)O

Technology Process of 1-Ethyl-3-hydroxypiperidine

There total 8 articles about 1-Ethyl-3-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl-3-piperidinone (43152-93-8) → 1-ethyl-3-hydroxypiperidine (13444-24-1)

Guidance literature:

With methanol; nickel; at 125 ℃; under 117681 Torr; Hydrogenation;

DOI:10.1021/ja01174a040

Reference yield:

1-ethyl-3-hydroxy-pyridinium; bromide (80866-84-8) → 1-ethyl-3-hydroxypiperidine (13444-24-1)

Guidance literature:

With methanol; rhodium contaminated with carbon; Hydrogenation;

DOI:10.1021/ja01528a030

Reference yield:

→ 1-ethyl-3-hydroxypiperidine (13444-24-1)

Guidance literature:

Verb. III in Eg. 1) HBr 2) KOH (Dest.);

upstream raw materials:

1-ethyl-3-piperidinone

1-ethyl-3-hydroxy-pyridinium; bromide

ethyl iodide

diethylamine

Downstream raw materials:

Benzo[d]isoxazol-3-yl-cyclohexyl-acetic acid 1-ethyl-piperidin-3-yl ester

3-(4-bromo-phenoxy)-1-ethyl-piperidine

N-(3-Chloro-4-methoxy-phenyl)-N'-cycloheptyl-6-(1-ethyl-piperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine

6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-3-oxy]benzoyl)benzo[b]thiophene

Refernces

• 1、 Mathison,Fowler,Peters. "New compounds: N,N-dimethyl-(3-1-alkylipiperidyl))carbamates, potential cholinesterase inhibitors.". . p. 158 - 160. Retrieved 2007/10/04.