OSW-1

Base Information

Chemical Name:OSW-1
CAS No.:145075-81-6
Molecular Formula:C47H68 O15
Molecular Weight:873.048
Hs Code.:
Mol file:145075-81-6.mol

Synonyms:OSW1; Orsaponin

Suppliers and Price of OSW-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
OSW-1,>90%(Orsaponin)
2.5mg
$ 910.00

Cayman Chemical
OSW-1
5mg
$ 780.00

Cayman Chemical
OSW-1
1mg
$ 371.00

Cayman Chemical
OSW-1
500μg
$ 195.00

American Custom Chemicals Corporation
OSW-1 95.00%
25MG
$ 2500.00

American Custom Chemicals Corporation
OSW-1 95.00%
5MG
$ 801.71

Total 40 raw suppliers

Chemical Property of OSW-1

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:932.5 °C at 760 mmHg
PKA:12.65±0.70(Predicted)
Flash Point:267 °C
PSA：216.97000
Density:1.31 g/cm³
LogP:4.02410
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

OSW-1,>90%(Orsaponin) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities. It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates. It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells. OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM. It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus. It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM. OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).
Uses OSW-1 is a unique steroidal saponin displaying selective cytotoxicity against cancer cell lines. From Ornithogalum Saundersiae bulbs.

Technology Process of OSW-1

There total 76 articles about OSW-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₇₁H₁₂₄O₁₅Si₄

: 145075-81-6
3β,16β,17α-trihydroxycholest-5-en-22-one 16-O-{O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-(1->3)-2-O-acetyl-β-L-arabinopyranoside}

Guidance literature:: With water; dichloro bis(acetonitrile) palladium(II); In acetone; at 20 ℃;
DOI:10.1021/jo051536b

Reference yield: 81.0%

: 335197-29-0
C₇₇H₁₁₆O₁₈Si₂

: 145075-81-6
3β,16β,17α-trihydroxycholest-5-en-22-one 16-O-{O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-(1->3)-2-O-acetyl-β-L-arabinopyranoside}

Guidance literature:: C₇₇H₁₁₆O₁₈Si₂; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 25 ℃; for 12h;

With bis(acetonitrile)palladium(II) dichloride; In water; acetone; at 25 ℃; for 2h; Further stages.;
DOI:10.1021/ja004098t