1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]-

Base Information

Chemical Name:1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]-
CAS No.:194606-12-7
Molecular Formula:C19H28O2
Molecular Weight:288.43
Hs Code.:

Synonyms:

Suppliers and Price of 1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]-

There total 2 articles about 1,3-Dioxepin, 2-(1,1-dimethylethyl)-4,5-dihydro-5-[4-(2-methylpropyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 53586-63-3
2-tert-butyl-4,7-dihydro-1,3-dioxepine

: 85609-09-2
1-iodo-4-isobutylbenzene

: 194606-12-7
2-tert-butyl-4,5-dihydro-5-(4-isobutylphenyl)-1,3-dioxepin

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 14h;
DOI:10.1016/S0957-4166(97)00237-1

Reference yield:

: 538-93-2
1-phenyl-2-methylpropane

: 194606-12-7
2-tert-butyl-4,5-dihydro-5-(4-isobutylphenyl)-1,3-dioxepin

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / trifluoromethanesulfonic acid, IPy₂BF₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 84 percent / i-Pr₂NEt, Pd(OAc)2, Ph₃P / dimethylformamide / 14 h / 80 °C

With palladium diacetate; Barluenga reagent; trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(97)00237-1

Reference yield:

: 194606-12-7
2-tert-butyl-4,5-dihydro-5-(4-isobutylphenyl)-1,3-dioxepin

: 51146-56-6,58560-75-1
(S)-ibuprofen

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH, RT, 12 h

2: 76 percent / lipase / diethyl ether / 6 h / Ambient temperature

3: 74 percent / Et₃N, 4-DMAP / CH₂Cl₂ / 3 h / Ambient temperature

4: 35 percent / NaBH₄ / dimethylsulfoxide / 12 h / 60 °C

5: 54 percent / CrO₃, H₂SO₄ / acetone / 0.5 h / 0 °C

With chromium(VI) oxide; dmap; sodium tetrahydroborate; sulfuric acid; ozone; triethylamine; lipase; In diethyl ether; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/S0957-4166(97)00237-1