ethyl 21,21,21-trifluoroapovincaminate

Base Information

• Chemical Name: ethyl 21,21,21-trifluoroapovincaminate
• CAS No.: 129959-03-1
• Molecular Formula: C₂₂H₂₃F₃N₂O₂
• Molecular Weight: 404.432
• Mol file: 129959-03-1.mol

Synonyms:Eburnamenine-14-carboxylicacid, 21,21,21-trifluoro-, ethyl ester, (?à)- (9CI);1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine,eburnamenine-14-carboxylic acid deriv.; Ethyl (?à)-21,21,21-trifluoroapovincaminate

Chemical Property of ethyl 21,21,21-trifluoroapovincaminate

Chemical Property:

• Vapor Pressure: 3.97E-07mmHg at 25°C
• Boiling Point: 415.9°C at 760 mmHg
• Flash Point: 205.3°C
• PSA: 34.47000
• Density: 1.4g/cm³
• LogP: 4.62860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 21,21,21-trifluoroapovincaminate

There total 4 articles about ethyl 21,21,21-trifluoroapovincaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.4%

Ethyl 3-<1α-(2,2,2-trifluoroethyl)-1,2,3,4,6,7,12,12bα-octahydroindolo-<2,3-a>-quinolizin-1β-yl>-2-hydroxyiminopropionate (129959-02-0,130060-82-1) → Ethyl 21,21,21-trifluoroapovincaminate (129959-03-1)

Guidance literature:

With sulfuric acid; In ethanol; for 2h; Heating;

DOI:10.1002/ardp.19903230604

Reference yield:

ethyl 3-bromo-2-(hydroxyimino)propanoate (73472-94-3) → Ethyl 21,21,21-trifluoroapovincaminate (129959-03-1)

Guidance literature:

Multi-step reaction with 2 steps

2: 76.4 percent / conc. H₂SO₄ / ethanol / 2 h / Heating

With sulfuric acid; In ethanol;

DOI:10.1002/ardp.19903230604

Reference yield:

1-(2,2,2-Trifluoroethyl)-1,2,3,4,6,7-hexahydro-12H-indolo-<2,3-a>-quinolizinium perchlorate → Ethyl 21,21,21-trifluoroapovincaminate (129959-03-1)

Guidance literature:

Multi-step reaction with 2 steps

2: 76.4 percent / conc. H₂SO₄ / ethanol / 2 h / Heating

With sulfuric acid; In ethanol;

DOI:10.1002/ardp.19903230604

upstream raw materials:

Ethyl 3-<1α-(2,2,2-trifluoroethyl)-1,2,3,4,6,7,12,12bα-octahydroindolo-<2,3-a>-quinolizin-1β-yl>-2-hydroxyiminopropionate

ethyl 3-bromo-2-(hydroxyimino)propanoate

1-(2,2,2-Trifluoroethyl)-1,2,3,4,6,7,12,12b-octahydroindolo-<2,3-a>-quinolizine

Refernces