73472-94-3Relevant articles and documents
Synthesis of some novel tricyclic α-aminoacid esters and potential bioactive compounds via 1,2-prototropy and 1,3-APT cascade reactions
Dondas, H. Ali,Dondas, Naciye Yaktubay
, p. 173 - 180 (2005)
Some novel cyclic α-aminoacid esters and potential bioactive compounds were prepared via thermal 1,2-prototropy- and 1,3-APT oxime nitrone-1,3-dipolar cycloaddition cascades reactions. This substrate allows the influence of the new stereocentres on the cascade to be assessed with respect to the configuration of the nitrone that is generated and the facial selectivity of the subsequent cycloaddition.
Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists
Pandya, Keyur,Dietrich, David,Seibert, Julia,Vederas, John C.,Odermatt, Alex
, p. 6274 - 6281 (2013)
11β-Hydroxyprogesterone is a well-known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11βHSD) types 1 and 2. It also activates the mineralocorticoid receptor (MR). Modulation of corticosteroid action by inhibition of 11βHSDs or blocking MR i
KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
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Paragraph 0212, (2019/10/15)
Described herein are compounds having the following structure: formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRKl A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
COMPOUNS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 194; 195, (2018/07/29)
Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.