Diazene-1,2-diylbis(morpholinomethanone)

Base Information

• Chemical Name: Diazene-1,2-diylbis(morpholinomethanone)
• CAS No.: 10465-82-4
• Molecular Formula: C₁₀H₁₆N₄O₄
• Molecular Weight: 256.261
• Hs Code.: 2934999090
• European Community (EC) Number: 418-690-0
• NSC Number: 356022
• UNII: 2GYM7S292E
• Mol file: 10465-82-4.mol

Synonyms:Diazene-1,2-diylbis(morpholinomethanone);Azodicarboxylic dimorpholide;10465-82-4;(NE)-N-(morpholine-4-carbonylimino)morpholine-4-carboxamide;Azodicarboxylic bismorpholide;NSC356022;NSC 356022;4,4'-((E)-Diazene-1,2-diyldicarbonyl)dimorpholine;4,4'-[(E)-Diazene-1,2-diyldicarbonyl]dimorpholine;SCHEMBL734044;AMY41227;MFCD00043006;AKOS015918854;AKOS037645882;CS-W014606;NSC-356022;AS-64477;Azodicarboxylic dimorpholide, >=98.0% (N);A855074;J-001216;N-[(morpholine-4-carbonyl)imino]morpholine-4-carboxamide

Chemical Property of Diazene-1,2-diylbis(morpholinomethanone)

Chemical Property:

• Vapor Pressure: 1.56E-06mmHg at 25°C
• Melting Point: 141-143 °C
• Boiling Point: 397.6°Cat760mmHg
• PKA: -0.97±0.20(Predicted)
• Flash Point: 194.3°C
• PSA: 83.80000
• Density: 1.46g/cm³
• LogP: 0.21880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 256.11715500
• Heavy Atom Count: 18
• Complexity: 303

Purity/Quality:

99.0% ^*data from raw suppliers

Azodicarboxylic dimorpholide ≥98.0% (N) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1C(=O)N=NC(=O)N2CCOCC2
• Isomeric SMILES: C1COCCN1C(=O)/N=N/C(=O)N2CCOCC2
• Uses: Azodicarboxylic dimorpholide has been used in the galanthamine ring system reaction that utilizes an intramolecular Heck reaction to establish the benzofuran ring system. Galanthamine exhibits potent acetylcholinesterase inhibitory activity and is important in the management of Alzheimer′s disease.

Technology Process of Diazene-1,2-diylbis(morpholinomethanone)

There total 4 articles about Diazene-1,2-diylbis(morpholinomethanone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

morpholine (110-91-8,99108-56-2) + diethylazodicarboxylate (1972-28-7,218603-74-8) → diazene-1,2-diylbis(morpholinomethanone) (10465-82-4)

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2018.10.029

Reference yield:

morpholine (110-91-8,99108-56-2) + diethyl diazodicarboxylate (4143-61-7,218603-74-8) → Azodicarbonsaeure-dimorpholid (10465-82-4)

Guidance literature:

Reference yield:

→ Azodicarbonsaeure-dimorpholid (10465-82-4)

Guidance literature:

Ester 7, Morpholin, Silberoxid;

DOI:10.1021/ja00426a054

upstream raw materials:

morpholine

diethylazodicarboxylate

diethyl diazodicarboxylate

Downstream raw materials:

N,N'-bis-(morpholine-4-carbonyl)-N-(toluene-4-sulfonyl)-hydrazine

N-(4-chloro-benzenesulfonyl)-N,N'-bis-(morpholine-4-carbonyl)-hydrazine

4,4'-(2-dianilinophosphoryl-2,3-diaza-butanedioyl)-bis-morpholine

N-cyclohexanesulfonyl-N,N'-bis-(morpholine-4-carbonyl)-hydrazine