Synonyms:DACA OEt;diazocarboxylic acid ethyl ester
99% *data from raw suppliers
Diethyl Azodicarboxylate *data from reagent suppliers
F,
Xn,
Xi
There total 27 articles about Diazocarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 95.0%
Reference yield: 88.0%
Reference yield: 61.0%
The research article details the synthesis of fluorinated cyclic hydrazine derivatives, which are significant due to their presence in biologically active compounds. The study employs ring-closing metathesis (RCM) as the key reaction to cyclize fluorinated and trifluoromethylated olefins into the desired hydrazines. The precursors for the RCM were prepared through a series of alkylation steps starting from diethyl azodicarboxylate or tert-butyl carbazate. The synthesized compounds were characterized using infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS). Crystallographic data for one of the synthesized hydrazines was also deposited, confirming its structure. The research provides a novel pathway to synthesize a potentially useful class of fluorinated cyclic hydrazines with potential pharmaceutical relevance.
The research investigates the liquid crystal properties of non-chiral and racemic branched alkyl chain molecules, specifically focusing on their ability to exhibit alternating tilt smectic phases. The purpose of the study was to understand how variations in the molecular structure, particularly the branching of terminal alkyl chains and the nature of the linking groups, influence the phase behavior of these compounds. The findings indicate that increased branching enhances the stability of alternating tilt smectic phases while suppressing other smectic phases. The study utilized various chemicals, including methyl 4-hydroxycinnamate, alkyl bromides, 4-hydroxybiphenyl-4'-carboxylic acid, and diethylazodicarboxylate (DEAD), in the synthesis of the target compounds. The results suggest that the molecular geometry and steric factors significantly impact the phase behavior of non-chiral liquid crystals.
The research focuses on the synthesis of solid-phase bound sulfonate esters, which are crucial in combinatorial chemistry and drug discovery due to their ability to bind molecules to polymer supports and facilitate the cleavage of target compounds. The study aimed to develop new polymer-bound synthetic methodologies using sulfonate linkers, specifically targeting the sulfonylation of secondary alcohols. The researchers utilized p-pivaloyloxybenzenesulfonyl and methylsulfonyl residues as linkers to attach secondary alcohols to Wang resin and Merrifield resin, respectively. Key chemicals involved in the process included p-pivaloyloxybenzenesulfonyl chloride, pyridine, sodium methoxide, and diethyl azodicarboxylate (DEAD), among others. The conclusions drawn from the research demonstrated that sulfonyl linkers could be easily attached to secondary alcohols and polymer terminals, either through the Mitsunobu reaction with Wang resin or alkylation with lithiated mesyl esters and Merrifield resin, without leaving any free sulfonyl-acid group on the resin, which is advantageous when working with acid-sensitive reactants.
The research focuses on the synthesis of tetracyclic derivatives through 1,3-dipolar cycloaddition reactions involving β-carboline azomethine ylides. The purpose of the study was to develop a method for accessing a novel class of 11H-indolizino[8,7-b]indoles, which are potentially useful in the synthesis of biologically targeted β-carboline derivatives. The key conclusions were that the reactions allowed for the formation of these complex structures, with the major product being the 1:1 adduct, and that the formation of by-products could be minimized but not entirely prevented. The chemicals used in the process included trimethylsilylmethyl triflate, diethyl azodicarboxylate (DEAD), cesium fluoride, sodium ethanolate, and various β-carboline derivatives. The study also investigated the effect of temperature and concentration on product distribution, providing insights into optimizing the reaction conditions for the desired outcomes.
The research focuses on the enantioselective syntheses of D- and L-ribo- and arabino-C,S-phytosphingosines, which are biologically important compounds found in plant sphingolipids and human brain and kidney lipids. The purpose of the study was to develop practical syntheses of these homochiral compounds from (R)-2,3-O-isopropylidene glyceraldehyde, utilizing key steps such as (Z)-selective olefination, selective monobenzoylation, Mitsunobu-type introduction of nitrogen, and osmylation. The conclusions drawn from the research indicate that the method is efficient, using inexpensive reagents and simple conditions suitable for gram-scale synthesis, and it also allows for the preparation of N- and O-protected derivatives, which could be useful for incorporating these compounds into biologically active ceramide and cerebroside structures. Chemicals used in the process include (R)-2,3-O-isopropylidene glyceraldehyde, phosphorane, benzoyl chloride, triphenylphosphine, diethyl azodicarboxylate, phthalimide, N-methyl-morpholine-N-oxide, osmium tetroxide, and various other reagents for protection and deprotection steps, as well as for chromatographic separation and analysis.
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