1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one
CAS No.:19621-24-0
Molecular Formula:C15H13NO2
Molecular Weight:239.274
Hs Code.:
DSSTox Substance ID:DTXSID10537392
Nikkaji Number:J2.621.691E
Wikidata:Q82412373

Synonyms:19621-24-0;1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-1-(4-methoxyphenyl)-;1-(4-methoxyphenyl)-2,3-dihydro-1H-indol-2-one;1-(4-Methoxyphenyl)-2(1H,3H)-indolone;1-[4-Methoxyphenyl)-2(1H,3H)-indolone;SCHEMBL6329014;DTXSID10537392;UZZNUBBBIPNJQU-UHFFFAOYSA-N;1-(4-Methoxyphenyl)indolin-2-one;4-methoxy-phenyl-1,3-dihydro-indol-2-one;1-(4-Methoxyphenyl)-2(1H, 3H)-indolone;1-(4-METHOXYPHENYL)-3H-INDOL-2-ONE

Suppliers and Price of 1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:239.094628657
Heavy Atom Count:18
Complexity:310

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2C(=O)CC3=CC=CC=C32

Technology Process of 1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one

There total 5 articles about 1-(4-Methoxyphenyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 59-48-3
2-oxoindole

: 696-62-8
para-iodoanisole

: 19621-24-0
3-(4-fluorophenyl)-3-benzylindolin-2-one

Guidance literature:: With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja803179s

Reference yield:

: 93597-01-4
1-(4-methoxyphenyl)indole

: 19621-24-0
3-(4-fluorophenyl)-3-benzylindolin-2-one

Guidance literature:: With N-chloro-succinimide; phosphoric acid; acetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, 2.) reflux;
DOI:10.1021/jm00122a025

Reference yield:

: 120-72-9
indole

: 19621-24-0
3-(4-fluorophenyl)-3-benzylindolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / K₂CO₃, Cu₂Br₂, N-methyl-2-pyrrolidinone

2: 1.) N-chlorosuccinimide, 2.) glacial acetic acid, 85percent H₃PO₄ / 1.) CH₂Cl₂, 2.) reflux

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; N-chloro-succinimide; phosphoric acid; potassium carbonate; acetic acid;
DOI:10.1021/jm00122a025