1-(4-methoxyphenyl)-1H-indole

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-1H-indole
• CAS No.: 93597-01-4
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• DSSTox Substance ID: DTXSID60354536
• Nikkaji Number: J1.188.300A
• Wikidata: Q82132745
• ChEMBL ID: CHEMBL1353671
• Mol file: 93597-01-4.mol

Synonyms:1-(4-methoxyphenyl)-1H-indole;93597-01-4;1-(4-methoxyphenyl)indole;ChemDiv3_001250;Cambridge id 5107542;CBDivE_002188;MLS001194500;(4-Methoxy-phenyl)1H-indole;SCHEMBL1078090;CHEMBL1353671;DTXSID60354536;CJJDJQFZVLGJLB-UHFFFAOYSA-N;1-(4-methoxy-phenyl)-1h-indole;HMS1476I18;HMS2879O03;IDI1_020216;SMR000555052;BRD-K41860776-001-01-3

Chemical Property of 1-(4-methoxyphenyl)-1H-indole

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2C=CC3=CC=CC=C32

Technology Process of 1-(4-methoxyphenyl)-1H-indole

There total 28 articles about 1-(4-methoxyphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

indole (120-72-9) + para-iodoanisole (696-62-8) → 1-(4-methoxyphenyl)indole (93597-01-4)

Guidance literature:

With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 24h; Reagent/catalyst; Catalytic behavior;

DOI:10.1039/d0nj04516k

Reference yield: 96.0%

indole (120-72-9) + 4-methoxyphenylboronic acid (5720-07-0) → 1-(4-methoxyphenyl)indole (93597-01-4)

Guidance literature:

With potassium carbonate; In methanol; at 60 ℃; for 6h;

DOI:10.1039/c9ra06991g

Reference yield: 96.0%

indole (120-72-9) + 1-bromo-4-methoxy-benzene (104-92-7) → 1-(4-methoxyphenyl)indole (93597-01-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1039/c7nj03240d

upstream raw materials:

indole

para-iodoanisole

1-bromo-4-methoxy-benzene

9H-carbazole

Downstream raw materials:

1-(4-methoxyphenyl)-3-(methylthio)-1H-indole

1-(4-methoxyphenyl)-1H-indole-3-carbonitrile

4-{[1-(4-methoxyphenyl)-1H-indol-3-yl]methyl}-N,N-dimethylbenzenamine

1,2,3,4-tetrahydro-1-[1-(4-methoxyphenyl)-1H-indol-3-yl]-2-phenylisoquinoline