3-(4-Methoxyphenyl)piperidine

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)piperidine
• CAS No.: 19725-26-9
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40513447
• Mol file: 19725-26-9.mol

Synonyms:3-(4-methoxyphenyl)piperidine;19725-26-9;Piperidine, 3-(4-methoxyphenyl)-;3-(4-methoxyphenyl)piperidine, AldrichCPR;SCHEMBL2145393;DTXSID40513447;XOFIBRNSGSEFHC-UHFFFAOYSA-N;MFCD09837353;AKOS004123314;AKOS016345410;SB41393;LS-02141;CS-0449151;FT-0679140;EN300-832799

Chemical Property of 3-(4-Methoxyphenyl)piperidine

Chemical Property:

• PSA: 21.26000
• LogP: 2.49100
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Methoxyphenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2CCCNC2

Technology Process of 3-(4-Methoxyphenyl)piperidine

There total 21 articles about 3-(4-Methoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-(4-methoxy-phenyl)-piperidin-2-one (19724-82-4) → 3-(4-methoxyphenyl)-piperidinehydrochloride (19725-26-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1.) 0.5 h, room temp., 2.) 4 h, reflux;

DOI:10.1248/cpb.30.180

Reference yield: 96.7%

3-(4-methoxyphenyl)pyridine (5958-02-1) → 3-(4-methoxyphenyl)-piperidinehydrochloride (19725-26-9)

Guidance literature:

With palladium diacetate; C₃H₆BNO₂; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

Reference yield: 96.0%

3-Bromopyridine (626-55-1,163928-56-1) + 4-methoxyphenylboronic acid (5720-07-0) → 3-(4-methoxyphenyl)-piperidinehydrochloride (19725-26-9)

Guidance literature:

3-Bromopyridine; 4-methoxyphenylboronic acid; With sodium phosphate dodecahydrate; palladium 10% on activated carbon; In isopropyl alcohol; at 80 ℃; for 6h;

With palladium 10% on activated carbon; hydrogen; acetic acid; In water; at 20 ℃; for 48h;

DOI:10.1002/jhet.4341

upstream raw materials:

5-(4-methoxy-phenyl)-piperidin-2-one

3-(4-methoxyphenyl)pyridine

1-methanesulfonyl-3-(4-methoxy-phenyl)-piperidine

3-(4-methoxyphenyl)-1-p-toluenesulfonylpiperidine

Downstream raw materials:

3-(4-methoxyphenyl)-1-propylpiperidine

4-(1-Propyl-piperidin-3-yl)-phenol; hydrobromide

3,4-Dimethoxy-benzoic acid 4-[3-(4-methoxy-phenyl)-piperidin-1-yl]-butyl ester; compound with toluene-4-sulfonic acid

4-[3-(4-Methoxy-phenyl)-piperidin-1-yl]-butan-1-ol

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