8-Hexadecanol

Base Information

• Chemical Name: 8-Hexadecanol
• CAS No.: 19781-83-0
• Molecular Formula: C16H34O
• Molecular Weight: 242.445
• Hs Code.: 2905199090
• Mol file: 19781-83-0.mol

Synonyms:octyl-octanol;Heptyloctylcarbinol;n-Hexadecanol-8;8-Hexadecanol;

Chemical Property of 8-Hexadecanol

Chemical Property:

• Vapor Pressure: 8.34E-05mmHg at 25°C
• Refractive Index: 1.4278 (estimate)
• Boiling Point: 304.4oC at 760 mmHg
• Flash Point: 117.8oC
• PSA: 20.23000
• Density: 0.834g/cm3
• LogP: 5.45840
• Water Solubility.: Soluble in water.

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Hexadecanol

There total 18 articles about 8-Hexadecanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

heptyl octyl ketone (18277-02-6) → 8-hexadecanol (19781-83-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1.5h;

Reference yield: 82.0%

n-hexylmagnesium chloride (44767-62-6) + 3-n-octyl-2,5-dioxathiolane 1,1-dioxide (117470-91-4) → 8-hexadecanol (19781-83-0)

Guidance literature:

n-hexylmagnesium chloride; 3-n-octyl-2,5-dioxathiolane 1,1-dioxide; With dilithium tetrachlorocuprate; In tetrahydrofuran; at 20 ℃; for 1h;

With sulfuric acid; In tetrahydrofuran; water; for 12h; chemoselective reaction;

DOI:10.1021/acs.orglett.6b01745

Reference yield:

Hexadecane (544-76-3) → 8-hexadecanol (19781-83-0)

Guidance literature:

With glucose dehydrogenase from Bacillus megaterium; cytochrome P₄₅₀ monooxygenase CYP₅₀₅E₃ from Aspergillus terreus; nicotinamide adenine dinucleotide; In aq. phosphate buffer; at 25 ℃; for 24h; regioselective reaction; Enzymatic reaction;

DOI:10.1002/anie.202001055

upstream raw materials:

Octanal

octylmagnesium bromide

heptyl octyl ketone

aluminum isopropoxide

Downstream raw materials:

heptyl octyl ketone

Hexadecane