18277-02-6

Basic information

• Product Name: 8-Hexadecanone
• CAS NO: 18277-02-6
• Molecular Formula: C16H32O
• Molecular Weight: 240.429
• Mol File: 18277-02-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 8-Hexadecanone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Hexadecanone(18277-02-6)
• EPA Substance Registry System: 8-Hexadecanone(18277-02-6)

Safety Data

• Hazardous Substances Data: 18277-02-6(Hazardous Substances Data)

Upstream product

• 4282-40-0 1-Iodoheptane 
• 629-27-6 1-Iodooctane 
• 111-66-0 oct-1-ene 
• 64531-26-6 1-chloro-1-octyne 
• 81438-46-2 1-iodooct-1-yne 
• 38761-67-0 1-bromo-1-octyne 
• 124-13-0 Octanal 
• 103687-22-5 ((CH₃)3C₆H₂)2BCHLiC₇H₁₅ 
• 19781-83-0 8-hexadecanol 
• 74-88-4 methyl iodide 
• 124-07-2 Octanoic acid 
• 111-64-8 n-octanoic acid chloride 
• 17049-49-9 octylmagnesium bromide 
• 200886-71-1 N-methoxy-N-methyloctanamide 

Downstream Products

• 19781-83-0 8-hexadecanol 

Relevant articles and documents

Cycloalkanones. 8. Hypocholesterolemic activity of long chain ketones related to pentadecanone

Aliphatic analogs of 2,8 dibenzylcyclooctanone which included C15-C18 ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2 Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this activity.

Removal of α-Hydroxy Group of Acyloins and Their Derivatives with Vanadium(II)-THF Complex

α-Hydroxy ketones (acyloins) and their acetate or mesylate derivatives were reduced to the corresponding ketones in good yields by treatment with 2 complex prepared in situ from VCl3(THF)3 and zinc.

IONIZABLE CATIONIC LIPID FOR RNA DELIVERY

What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

Practical one-pot preparation of ketones from aryl and alkyl bromides with aldehydes and DIH via Grignard reagents

Various diaryl ketones, alkyl aryl ketones, and dialkyl ketones were efficiently prepared in good yields by the reactions of the Grignard reagents derived from aryl or alkyl bromides, followed by the reactions with aromatic or aliphatic aldehydes and the subsequent treatment with 1,3-diiodo-5,5- dimethylhydantoin and K2CO3, in a one-pot method. The same treatment of aromatic bromides bearing electron-withdrawing groups, such as ester, nitrile, ketone, and nitro groups with i-PrMgCl·LiCl or PhMgCl instead of Mg, also provided the corresponding diaryl and alkyl aryl ketones in good yields. The above methods are simple and practical transition-metal-free methods for the preparation of various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatic groups and electron-deficient aromatic groups, as well as dialkyl ketones.