BOC-PHG-OSU

Base Information

• Chemical Name: BOC-PHG-OSU
• CAS No.: 201152-47-8
• Molecular Formula: C17H20N2O6
• Molecular Weight: 348.356
• Mol file: 201152-47-8.mol

Synonyms:BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDESTER;BOC-L-PHENYLGLYCINE N-HYDROXYSUCCINIMIDE ESTER;BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDE ESTER;BOC-PHENYLGLYCINE-OSU;

Chemical Property of BOC-PHG-OSU

Chemical Property:

• PSA: 102.01000
• LogP: 2.18840
• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

Boc-L-phenylglycine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-PHG-OSU

There total 3 articles about BOC-PHG-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) → Boc-Phg-OSu (201152-47-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm00113a025

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Boc-Phg-OSu (201152-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / tetrahydrofuran / 12 h / 23 °C

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C

With sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

Reference yield:

(S)-2-phenylglycine (2935-35-5) → Boc-Phg-OSu (201152-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / tetrahydrofuran / 12 h / 23 °C

2: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / dioxane / 2 h / 23 °C

With sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

di-tert-butyl dicarbonate

(S)-2-phenylglycine

Downstream raw materials:

(S)-tert-butyl (2-(benzylamino)-2-oxo-1-phenylethyl)carbamate

spiro[(4-ethyl-7,8-dihydropyrano[3,2-g]chromen-2-one)-8,1'-cyclohexane] N-(N-tert-butyloxycarbonyl-L-2-phenylglycyl)hydrazone

[(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

{(1S,2S,4R)-1-Benzyl-4-[((S)-benzylcarbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester