(3S)-3-FMOC-AMINO-1-DIAZO-2-BUTANONE

Base Information

• Chemical Name: (3S)-3-FMOC-AMINO-1-DIAZO-2-BUTANONE
• CAS No.: 201864-70-2
• Molecular Formula: C21H19N3O3
• Molecular Weight: 361.39400
• Mol file: 201864-70-2.mol

Synonyms:FMOC-L-ALA-CHN2;FMOC-L-PRO-CHN2;Fmoc-Pro-DAM;(S)-2-DIAZOACETYL-PYRROLIDINE-1-CARBOXYLIC ACID (9-FLUORENYLMETHYL) ESTER;

Chemical Property of (3S)-3-FMOC-AMINO-1-DIAZO-2-BUTANONE

Chemical Property:

• PSA: 84.00000
• LogP: 3.28856

Purity/Quality:

98% ^*data from raw suppliers

(S)-2-DIAZOACETYL-PYRROLIDINE-1-CARBOXYLIC ACID-(9-FLUORENYLMETHYL)ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S)-3-FMOC-AMINO-1-DIAZO-2-BUTANONE

There total 6 articles about (3S)-3-FMOC-AMINO-1-DIAZO-2-BUTANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Fmoc-Pro-OH (71989-31-6) → Fmoc-Pro-DAM (201864-70-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

Reference yield:

Fmoc-Pro-OH (71989-31-6) → Fmoc-Pro-DAM (201864-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 0.25 h / -25 - -20 °C

2: tetrahydrofuran; diethyl ether / 0 °C

With triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1002/hlca.19980810107

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (S)-2-Ethoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester → Fmoc-Pro-DAM (201864-70-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; Yield given;

DOI:10.1002/hlca.19980810107

upstream raw materials:

diazomethane

Fmoc-Pro-OH

(S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

Fmoc-β³-HPro-OH