4-Methylpyridine-2,6-diamine

Base Information

• Chemical Name: 4-Methylpyridine-2,6-diamine
• CAS No.: 38439-33-7
• Molecular Formula: C6H9 N3
• Molecular Weight: 123.158
• Hs Code.: 2933399090
• European Community (EC) Number: 253-931-1
• DSSTox Substance ID: DTXSID60191761
• Nikkaji Number: J294.660B
• Wikidata: Q72496607
• Mol file: 38439-33-7.mol

Synonyms:4-Methylpyridine-2,6-diamine;38439-33-7;2,6-Pyridinediamine, 4-methyl-;2,6-DIAMINO-4-METHYLPYRIDINE;2,6-DIAMINO-4-METHYL PYRIDINE;EINECS 253-931-1;4-Methyl-pyridine-2,6-diamine;4-Methyl-2,6-pyridinediamine;SCHEMBL105871;4-methyl-pyridin-2,6-diamine;DTXSID60191761;HUQGLWLBOCSVMD-UHFFFAOYSA-N;MFCD00129027;AKOS006273864;DS-15808;A6513;FT-0748853;F11134

Chemical Property of 4-Methylpyridine-2,6-diamine

Chemical Property:

• Boiling Point: 312.5°Cat760mmHg
• Flash Point: 168.5°C
• PSA: 64.93000
• Density: 1.19g/cm³
• LogP: 1.71680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.3

Purity/Quality:

98%, ^*data from raw suppliers

4-Methylpyridine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1)N)N
• Uses: 4-Methylpyridine-2,6-diamine is a reactant in the preparation of N-(pyridin-2-yl) arylsulfonamides with potent 11β-hydroxysteroid dehydrogenase type 1 activity.

Technology Process of 4-Methylpyridine-2,6-diamine

There total 5 articles about 4-Methylpyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Amino-4-methylpyridine (695-34-1) → 2,6-diamino-4-methylpyridine (38439-33-7)

Guidance literature:

With tetralin; sodium amide; at 200 ℃; for 4h; Inert atmosphere;

DOI:10.1039/d1ob01433a

Reference yield: 66.0%

picoline (108-89-4) → 2,6-diamino-4-methylpyridine (38439-33-7)

Guidance literature:

With sodium amide; In mineral oil; at 20 - 215 ℃;

DOI:10.1016/j.tetlet.2015.12.013

Reference yield:

2,6-Dibromo-4-methylpyridine (73112-16-0) → 2,6-diamino-4-methylpyridine (38439-33-7)

Guidance literature:

With ammonium hydroxide; at 195 ℃;

DOI:10.1021/ja01197a047

upstream raw materials:

picoline

2,6-Dibromo-4-methylpyridine

4-methyl-2,6-dihydroxypyridine

2-Amino-4-methylpyridine

Refernces

• 1、 Bella, Giovanni,Castriciano, Maria Angela,Collini, Elisabetta,Cordaro, Massimiliano,Trapani, Mariachiara. "Supramolecular BODIPY based dimers: synthesis, computational and spectroscopic studies". . p. 8118 - 8127. Retrieved 2021/10/04.
• 2、 -. "NOVEL COMPOUNDS OF AMINO SULFONYL DERIVATIVES". Page/Page column 29. . Retrieved 2010/11/24.