Silane, (1,1-dimethylethyl)[[(1S)-1-methyl-4-pentynyl]oxy]diphenyl-

Base Information

Chemical Name:Silane, (1,1-dimethylethyl)[[(1S)-1-methyl-4-pentynyl]oxy]diphenyl-
CAS No.:203387-37-5
Molecular Formula:C22H28OSi
Molecular Weight:336.549
Hs Code.:

Synonyms:

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Chemical Property of Silane, (1,1-dimethylethyl)[[(1S)-1-methyl-4-pentynyl]oxy]diphenyl-

Chemical Property:

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Technology Process of Silane, (1,1-dimethylethyl)[[(1S)-1-methyl-4-pentynyl]oxy]diphenyl-

There total 8 articles about Silane, (1,1-dimethylethyl)[[(1S)-1-methyl-4-pentynyl]oxy]diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 668461-27-6
(5S)-1,1-dibromo-5-(tert-butyl(diphenyl)silyloxy)-1-hexene

: 203387-37-5
(5S)-5-(tert-butyl(diphenyl)silyloxy)-1-hexyne

Guidance literature:: With magnesium; ethylene dibromide; In tetrahydrofuran; Heating;
DOI:10.1021/jo035391p

Reference yield:

: 102732-44-5
ethyl (S)-2-(tert-butyldiphenylsilyloxy)propanoate

: 203387-37-5
(5S)-5-(tert-butyl(diphenyl)silyloxy)-1-hexyne

Guidance literature:: Multi-step reaction with 6 steps

1.1: DIBAL-H / diethyl ether; toluene / 2 h / -90 °C

2.1: NaH / tetrahydrofuran / 2 h

2.2: 75 percent / diethyl ether / 16 h / 22 °C

3.1: 83 percent / H₂; Raney nickel / methanol / 4500.36 Torr

4.1: 94 percent / DIBAL-H / diethyl ether; toluene / 2 h / -90 °C

5.1: triphenylphosphine; Zn / CH₂Cl₂ / 16 h / 20 °C

5.2: 75 percent / pyridine / CH₂Cl₂ / 2 h

6.1: 91 percent / Mg; 1,2-dibromoethane / tetrahydrofuran / Heating

With hydrogen; nickel; sodium hydride; diisobutylaluminium hydride; magnesium; ethylene dibromide; triphenylphosphine; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 2.1: Horner-Wadsworth-Simmons olefination;
DOI:10.1021/jo035391p

Reference yield:

: 87696-33-1
(S)-2-(O-tert-butyldiphenylsilyloxy)propanal

: 203387-37-5
(5S)-5-(tert-butyl(diphenyl)silyloxy)-1-hexyne

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 2 h

1.2: 75 percent / diethyl ether / 16 h / 22 °C

2.1: 83 percent / H₂; Raney nickel / methanol / 4500.36 Torr

3.1: 94 percent / DIBAL-H / diethyl ether; toluene / 2 h / -90 °C

4.1: triphenylphosphine; Zn / CH₂Cl₂ / 16 h / 20 °C

4.2: 75 percent / pyridine / CH₂Cl₂ / 2 h

5.1: 91 percent / Mg; 1,2-dibromoethane / tetrahydrofuran / Heating

With hydrogen; nickel; sodium hydride; diisobutylaluminium hydride; magnesium; ethylene dibromide; triphenylphosphine; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 1.1: Horner-Wadsworth-Simmons olefination;
DOI:10.1021/jo035391p