10.1002/jhet.5570320225
The research aimed to synthesize a series of N'-substituted 1,4-benzodiazepine-1-carbothioamides (2a-j) and investigate their anti-HIV activity. The researchers used a precursor, 1,4-benzodiazepine 11, and reacted it with various N-substituted isothiocyanates or sodium thiocyanate-trifluoroacetic acid to create the target compounds. Key chemicals involved in the synthesis included 2-aminobenzyl alcohol, di-tert-butyl dicarbonate, carbon tetrabromide, triphenylphosphine, L-alanine, and different isothiocyanates. Despite the structural resemblance of these molecules to the potent TIBO-type anti-HIV compound R82150, none of the synthesized compounds displayed anti-HIV activity in vitro, suggesting that the potent anti-HIV activity of TIBO derivatives requires an intact tricyclic structure.
10.1055/s-0034-1380493
The research aimed to develop an efficient and environmentally benign method for the synthesis of 1,3,4-oxadiazoles, which are important heterocyclic compounds with a broad spectrum of biological activities and applications in medicinal chemistry. The study focused on the photoredox-catalyzed oxidative heterocyclization of semicarbazones using eosin Y as a visible-light photocatalyst and carbon tetrabromide (CBr4) as a bromine source. The process involved the irradiation of the reaction mixture with green LEDs under atmospheric oxygen, leading to the formation of 5-substituted 2-amino-1,3,4-oxadiazoles in high yields (86–96%) within 10–14 hours. The researchers concluded that this method offered a rapid, mild, and operationally simple approach to synthesize valuable 1,3,4-oxadiazoles, utilizing visible light and atmospheric oxygen, and was superior to traditional methods that often required harsh conditions and multistep processes.
T+,
Xi,
N
