3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one

Base Information

Chemical Name:3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one
CAS No.:204703-66-2
Molecular Formula:C15H11ClO3
Molecular Weight:274.704
Hs Code.:
DSSTox Substance ID:DTXSID80709443

Synonyms:DTXSID80709443;3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one

Suppliers and Price of 3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:274.0396719
Heavy Atom Count:19
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C=CC(=O)C2=C(C=CC(=C2)O)O)Cl

Technology Process of 3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one

There total 5 articles about 3-(4-Chlorophenyl)-1-(2,5-dihydroxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 204703-69-5
2',5'-bis(tetrahydropyran-2-yloxy)-4-chlorochalcone

: 204703-66-2
2',5'-dihydroxy-4-chlorochalcone

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 4h;
DOI:10.1016/S0223-5234(02)01443-5

Reference yield:

: 490-78-8
2,5-Dihydroxyacetophenone

: 204703-66-2
2',5'-dihydroxy-4-chlorochalcone

Guidance literature:: Multi-step reaction with 3 steps

1: pyridium p-toluenesulfonate / 20 °C

2: barium hydroxide octahydrate / 40 °C

3: 4.29 g / p-toluenesulfonic acid / 20 °C

With pyridium para-toluenesulfonate; barium hydroxide octahydrate; toluene-4-sulfonic acid; 2: Claisen-Schmidt condensation;
DOI:10.1016/j.ejmech.2004.09.006

Reference yield:

: 204703-68-4
2',5'-bis(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)acetophenone

: 204703-66-2
2',5'-dihydroxy-4-chlorochalcone

Guidance literature:: Multi-step reaction with 2 steps

1: barium hydroxide octahydrate / 40 °C

2: 4.29 g / p-toluenesulfonic acid / 20 °C

With barium hydroxide octahydrate; toluene-4-sulfonic acid; 1: Claisen-Schmidt condensation;
DOI:10.1016/j.ejmech.2004.09.006