Technology Process of Benzoic acid, 2-[(trimethylsilyl)ethynyl]-
There total 3 articles about Benzoic acid, 2-[(trimethylsilyl)ethynyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; water;
In
tert-butyl alcohol;
at 0 ℃;
for 2.25h;
DOI:10.1021/acs.orglett.8b03275
- Guidance literature:
-
2-bromo-1-(trimethylsilylethynyl)benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -80 ℃;
for 1h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -80 - 20 ℃;
for 15h;
Inert atmosphere;
With
hydrogenchloride;
In
water;
DOI:10.1002/adsc.201801308
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / Inert atmosphere
1.2: Inert atmosphere
2.1: water; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / tert-butyl alcohol / 2.25 h / 0 °C
With
bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; sodium dihydrogenphosphate; copper(l) iodide; 2-methyl-but-2-ene; water; triethylamine;
In
N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/acs.orglett.8b03275
