Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Base Information

• Chemical Name: Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• CAS No.: 205812-07-3
• Molecular Formula: C22H25NO5
• Molecular Weight: 383.43800
• Mol file: 205812-07-3.mol

Synonyms:N-Fmoc-O-tert-butyl-DL-serine;

Chemical Property of Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Chemical Property:

• PSA: 84.86000
• LogP: 4.18430

Purity/Quality:

97% ^*data from raw suppliers

N-Fmoc-O-tert-butyl-DL-serine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

There total 1 articles about Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester → N-(9-fluorenylmethoxycarbonyl)-DL-serine (136083-72-2) + Fmoc-DL-Ser-(OtBu)-OH (205812-07-3)

Guidance literature:

With zinc dibromide; In dichloromethane; for 2h;

DOI:10.1016/S0040-4039(00)00300-2

Reference yield: 97.0%

cyclohexylamine (108-91-8,157973-60-9) + Fmoc-DL-Ser-(OtBu)-OH (205812-07-3) → C28H36N2O4

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃;

DOI:10.1039/d0cc08309g

Reference yield: 85.0%

Fmoc-DL-Ser-(OtBu)-OH (205812-07-3) → Fmoc-DL-Ser(tBu)-ol (883021-54-3)

Guidance literature:

Fmoc-DL-Ser-(OtBu)-OH; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.25h;

With hydrogenchloride; In tetrahydrofuran; water;

Downstream raw materials:

Fmoc-DL-Ser(tBu)-ol

C₄₀H₄₃NO₉

2-amino-3-tert-butoxypropionic acid

human C-type natriuretic peptide 22