O-tert-Butyl-DL-serine

Base Information

• Chemical Name: O-tert-Butyl-DL-serine
• CAS No.: 17083-25-9
• Molecular Formula: C₇H₁₅NO₃
• Molecular Weight: 161.201
• UNII: 8HF4U4Q747
• Mol file: 17083-25-9.mol

Synonyms:O-tert-Butyl-DL-serine;17083-25-9;2-amino-3-(tert-butoxy)propanoic acid;Alanine, 3-tert-butoxy-, DL-;8HF4U4Q747;DL-Serine, O-(1,1-dimethylethyl)-;MFCD00066088;MFCD00077107;2-amino-3-[(2-methylpropan-2-yl)oxy]propanoic Acid;(R)-2-Amino-3-(tert-butoxy)propanoic acid;O-tert.butyl-dl-serine;SCHEMBL561163;UNII-8HF4U4Q747;DDCPKNYKNWXULB-UHFFFAOYSA-N;STR07148;2-amino-3-tert-butoxy propionic acid;AKOS009159387;SY031318;SY032305;FT-0637754;FT-0695791;C77965;EN300-202452;A880558

Chemical Property of O-tert-Butyl-DL-serine

Chemical Property:

• XLogP3: -2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 161.10519334
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98.5% ^*data from raw suppliers

O-tert-Butyl-DL-serine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OCC(C(=O)O)N

Technology Process of O-tert-Butyl-DL-serine

There total 4 articles about O-tert-Butyl-DL-serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-O-t-Bu-DL-serine (14464-36-9) → 2-amino-3-tert-butoxypropionic acid (17083-25-9,29435-39-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja00885a020

Reference yield:

(R)-methyl 2-(benzyloxycarbonylamino)-3-t-butoxypropanoate (155526-66-2) → 2-amino-3-tert-butoxypropionic acid (17083-25-9,29435-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: H₂ / Pd-C / ethanol

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja00885a020

Reference yield:

Fmoc-DL-Ser-(OtBu)-OH (205812-07-3) → 2-amino-3-tert-butoxypropionic acid (17083-25-9,29435-39-0)

Guidance literature:

With piperidine; In tetrahydrofuran; for 3h;

upstream raw materials:

N-Cbz-O-t-Bu-DL-serine

(R)-methyl 2-(benzyloxycarbonylamino)-3-t-butoxypropanoate

Fmoc-DL-Ser-(OtBu)-OH

Downstream raw materials:

t-Bumeoc-Ser-(t-Bu)-OH*DCHA

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione