Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]-

Base Information

Chemical Name:Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]-
CAS No.:207918-38-5
Molecular Formula:C16H23NO3
Molecular Weight:277.364
Hs Code.:
DSSTox Substance ID:DTXSID30446957
Nikkaji Number:J994.281E

Synonyms:207918-38-5;Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]-;SCHEMBL8686368;DTXSID30446957;SCHCXYCYWYJEDA-UHFFFAOYSA-N;N-ethyl-N-[2-(tetrahydropyran-2-yl)oxyethyl]-4-formylaniline;4-[Ethyl[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino]benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:277.16779360
Heavy Atom Count:20
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CCOC1CCCCO1)C2=CC=C(C=C2)C=O

Technology Process of Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]-

There total 4 articles about Benzaldehyde, 4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 63619-28-3
4-(N-ethyl-N-(2-hydroxyethyl)amino)benzaldehyde

: 207918-38-5
4-{N-ethyl-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl] amino}benzaldehyde

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/s0040-4039(98)01499-3

Reference yield:

: 92-50-2
2-( N-ethylanilino)ethanol

: 207918-38-5
4-{N-ethyl-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl] amino}benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcCl; NEt₃ / tetrahydrofuran

1.2: POCl₃ / 70 °C

1.3: 88 percent / Na₂CO₃ / methanol; H₂O / 20 °C

2.1: 99 percent / PPTS / CH₂Cl₂ / 24 h / 20 °C

With pyridinium p-toluenesulfonate; triethylamine; acetyl chloride; In tetrahydrofuran; dichloromethane; 1.2: Vilsmeyer-Haack formylation;

Reference yield:

: 51920-03-7
1-(N-ethyl-anilino)-2-benzoyloxy-ethane

: 207918-38-5
4-{N-ethyl-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl] amino}benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃ / 6 h / 90 °C

2: 5 percent NaOH / methanol; H₂O / 1 h / Heating

3: PPTS / CH₂Cl₂ / 24 h / 20 °C

With sodium hydroxide; pyridinium p-toluenesulfonate; trichlorophosphate; In methanol; dichloromethane; water; 1: Formylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1016/S0040-4039(99)01443-4