(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

Base Information

Chemical Name:(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal
CAS No.:250386-01-7
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

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Chemical Property of (2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

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Technology Process of (2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

There total 8 articles about (2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 115754-62-6
(1,3-dioxolan-2-ylmethyl)tributylphosphonium bromide

: 207918-38-5
4-{N-ethyl-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl] amino}benzaldehyde

: 250386-01-7
(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

Guidance literature:: (1,3-dioxolan-2-ylmethyl)tributylphosphonium bromide; 4-{N-ethyl-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl] amino}benzaldehyde; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 19h;

With acetic acid; In dichloromethane; water; at 20 ℃; for 60h; Further stages.;
DOI:10.1039/b615628b

Reference yield:

: 250386-10-8
[4-((E)-2-[1,3]Dioxolan-2-yl-vinyl)-phenyl]-ethyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amine

: 250386-01-7
(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

Guidance literature:: With silica gel; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(99)01443-4

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 250386-01-7
(2E)-3-[4-[ethyl[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]amino]phenyl]-propenal

Guidance literature:: Multi-step reaction with 3 steps

1: PPTS / CH₂Cl₂ / 24 h / 20 °C

2: t-BuOK; 18-O-6 / CH₂Cl₂ / 20 h / 20 °C

3: SiO₂ / CH₂Cl₂; ethanol

With potassium tert-butylate; pyridinium p-toluenesulfonate; silica gel; In ethanol; dichloromethane; 1: Etherification / 2: Wittig reaction / 3: Hydrolysis;
DOI:10.1016/S0040-4039(99)01443-4