Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS No.:208655-84-9
Molecular Formula:C22H33N4O9P
Molecular Weight:528.49300
Hs Code.:

Synonyms:Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester;2',3'-di-O-acetyl-5'-O-(2-cyanoethyl)-N,N-diisopropylaminophosphoramidete;

Suppliers and Price of Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2’,3’-Di-O-acetyl-U-5’-CEP
50mg
$ 440.00

TRC
2’,3’-Di-O-acetyl-U-5’-CEP
25mg
$ 250.00

TRC
2’,3’-Di-O-acetyl-U-5’-CEP
10mg
$ 110.00

TRC
2’,3’-Di-O-acetyl-U-5’-CEP
5mg
$ 60.00

Total 0 raw suppliers

Chemical Property of Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

PSA：175.77000
LogP:1.58998

Purity/Quality:: 2’,3’-Di-O-acetyl-U-5’-CEP ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2’,3’-Di-O-acetyl-U-5’-CEP is a reagent used in the biosynthesis of C-glycosidic UDP-GlcNAc analogs as substrate-based inhibitors of UDP-GlcNAc 2-epimerase.

Technology Process of Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 4 articles about Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 29108-90-5
2',3'-di-O-acetyl-uridine

: 208655-84-9
2',3'-di-O-acetyluridine-5'-O-yl(2-cyanoethoxy)(diisopropylamino)phosphane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo802021t

Reference yield: 95.0%

: 29108-90-5
2',3'-di-O-acetyl-uridine

: 2-cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite

: 208655-84-9
2',3'-di-O-acetyluridine-5'-O-yl(2-cyanoethoxy)(diisopropylamino)phosphane

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200400197

Reference yield:

: 111426-09-6
1-[2',3'-di-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-β-D-ribo-pentofuranosyl]-uracil

: 208655-84-9
2',3'-di-O-acetyluridine-5'-O-yl(2-cyanoethoxy)(diisopropylamino)phosphane

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water; methanol / 18 h / 50 °C

2: 4,5-dicyano-1H-imidazole / acetonitrile / 1 h

With 4,5-dicyano-1H-imidazole; acetic acid; In methanol; water; acetonitrile;
DOI:10.1002/chem.201801083