(6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one

Base Information

Chemical Name:(6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one
CAS No.:209257-74-9
Molecular Formula:C22H29NO2Si
Molecular Weight:367.563
Hs Code.:
DSSTox Substance ID:DTXSID80572316
Nikkaji Number:J964.455E
Wikidata:Q82460617

Synonyms:209257-74-9;DTXSID80572316;(6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one

Suppliers and Price of (6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:367.196755702
Heavy Atom Count:26
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCC3CCCC(=O)N3
Isomeric SMILES:CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OC[C@H]3CCCC(=O)N3

Technology Process of (6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one

There total 6 articles about (6R)-6-({[tert-Butyl(diphenyl)silyl]oxy}methyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 213532-99-1
(R)-5-Azido-6-(tert-butyl-diphenyl-silanyloxy)-hexanoic acid 4-methoxy-benzyl ester

: 209257-74-9
(6R)-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 760 Torr; Ambient temperature;
DOI:10.1055/s-1998-2123

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 209257-74-9
(6R)-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 82 percent / NaN₃ / dimethylformamide / 18 h / 80 °C

4: 84 percent / H₂ / Pd/C / ethanol / 18 h / 760 Torr / Ambient temperature

With 1H-imidazole; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-2123

Reference yield:

: 187851-95-2
(4-methoxyphenyl)methyl hex-5-enoate

: 209257-74-9
(6R)-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / 1,4-bis(dihydroquininyl)anthraquinone, K₃Fe(CN)6, K₂CO₃, NaHCO₃, potassium osmate(VI) dihydrate, H₂O / 2-methyl-propan-2-ol / 12 h / 0 °C

2: 91 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 82 percent / NaN₃ / dimethylformamide / 18 h / 80 °C

5: 84 percent / H₂ / Pd/C / ethanol / 18 h / 760 Torr / Ambient temperature

With 1H-imidazole; potassium osmate(VI); sodium azide; 1,4-bis(dihydroquinidinyl)anthraquinone; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1055/s-1998-2123