2-hydroxy-5-(trifluoroMethyl)benzaldehyde

Base Information

• Chemical Name: 2-hydroxy-5-(trifluoroMethyl)benzaldehyde
• CAS No.: 210039-65-9
• Molecular Formula: C8H5F3O2
• Molecular Weight: 190.122
• Mol file: 210039-65-9.mol

Synonyms:5-trifluoromethyl-2-hydroxybenzaldehyde;2-hydroxy-4-trifluoromethyl benzaldehyde;2-hydroxy-5-trifluoromethylbenzaldehyde;5-trifluoromethylsalicylaldehyde;

Chemical Property of 2-hydroxy-5-(trifluoroMethyl)benzaldehyde

Chemical Property:

• Melting Point: 59-60 °C
• Boiling Point: 204.5±35.0 °C(Predicted)
• PKA: 6.77±0.18(Predicted)
• PSA: 37.30000
• Density: 1.429±0.06 g/cm3(Predicted)
• LogP: 2.22350
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-5-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-5-(trifluoroMethyl)benzaldehyde

There total 13 articles about 2-hydroxy-5-(trifluoroMethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxy-5-(trifluoromethyl)benzaldehyde (146539-83-5) → 2-hydroxy-5-(trifluoromethyl)benzaldehyde (210039-65-9)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 2.5h;

Reference yield: 75.0%

2-[(4-trifluoromethyl)phenoxy]tetrahydro-2H-pyrane (134142-88-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-hydroxy-5-(trifluoromethyl)benzaldehyde (210039-65-9)

Guidance literature:

3-[4-(trifluoromethyl)phenoyl]tetrahydro-2-H-pyran; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; at -10 ℃; for 2h;

N,N-dimethyl-formamide; In hexane; for 0.25h;

With hydrogenchloride; In hexane;

DOI:10.1055/s-2001-18440

Reference yield: 75.0%

→ 2-hydroxy-5-(trifluoromethyl)benzaldehyde (210039-65-9)

Guidance literature:

upstream raw materials:

2-[(4-trifluoromethyl)phenoxy]tetrahydro-2H-pyrane

N,N-dimethyl-formamide

2-bromo-4-(trifluoromethyl)phenol

2-tetrahydropyran-2-yloxy-5-(trifluoromethyl)benzaldehyde

Downstream raw materials:

5-trifluoromethyl-2-(4-methoxybenzyloxy)-benzaldehyde

1-[5-trifluoromethyl-2-(benzyloxy)-phenyl]-pentane-1,4-dione

1-[5-trifluoromethyl-2-(4-methoxybenzyloxy)phenyl]-pentane-1,4-dione

3-{2-[5-trifluoromethyl-2-(hydroxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester