1-(2-Tert-butylphenyl)pyrrolidine-2,5-dione

Base Information

• Chemical Name: 1-(2-Tert-butylphenyl)pyrrolidine-2,5-dione
• CAS No.: 210426-64-5
• Molecular Formula: C14H17NO2
• Molecular Weight: 231.294
• DSSTox Substance ID: DTXSID60445079
• Nikkaji Number: J1.294.032G
• Mol file: 210426-64-5.mol

Synonyms:1-(2-tert-butylphenyl)pyrrolidine-2,5-dione;210426-64-5;SCHEMBL2051520;N-(2-t-butylphenyl)succinimide;2,5-Pyrrolidinedione, 1-[2-(1,1-dimethylethyl)phenyl]-;DTXSID60445079;CIBSFDWYFFHZRU-UHFFFAOYSA-N

Chemical Property of 1-(2-Tert-butylphenyl)pyrrolidine-2,5-dione

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 231.125928785
• Heavy Atom Count: 17
• Complexity: 314

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC=CC=C1N2C(=O)CCC2=O

Technology Process of 1-(2-Tert-butylphenyl)pyrrolidine-2,5-dione

There total 3 articles about 1-(2-Tert-butylphenyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Succinimide (123-56-8,89963-74-6) + tert-butylbenzene (253185-03-4,253185-04-5) → C14H17NO2 (1438436-46-4) + C14H17NO2 (98604-38-7) + 1-(2-tert-butylphenyl)-pyrrolidine-2,5-dione (210426-64-5)

Guidance literature:

With tri-tert-butyl phosphine; [bis(acetoxy)iodo]benzene; palladium diacetate; at 100 ℃; for 33h; Overall yield = 24 %; Inert atmosphere; Glovebox;

DOI:10.1021/ja4032677

Reference yield:

succinic acid anhydride (108-30-5) + 2-(1,1-dimethylethyl)-benzenamine (6310-21-0) → 1-(2-tert-butylphenyl)-pyrrolidine-2,5-dione (210426-64-5)

Guidance literature:

With sodium acetate; acetic anhydride; Yield given. Multistep reaction; 1.), 2.) reflux;

DOI:10.1080/00397919808007182

Reference yield:

2-(1,1-dimethylethyl)-benzenamine (6310-21-0) → 1-(2-tert-butylphenyl)-pyrrolidine-2,5-dione (210426-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: 1.43 g / sodium acetate; acetic anhydride / 70 - 80 °C

With sodium acetate; acetic anhydride; In toluene;

DOI:10.1016/j.tet.2004.01.100

upstream raw materials:

succinic acid anhydride

2-(1,1-dimethylethyl)-benzenamine

Succinimide

tert-butylbenzene

Downstream raw materials:

1-(2-tert-butylphenyl)-5-hydroxypyrrolidin-2-one

3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione