tert-butyl 2-(2-broMoethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(2-broMoethyl)piperidine-1-carboxylate
• CAS No.: 210564-52-6
• Molecular Formula: C12H22BrNO2
• Molecular Weight: 292.21300
• Mol file: 210564-52-6.mol

Synonyms:2-[N-(tert-butyloxycarbonyl)-2-piperidinyl]ethyl bromide;2-(2-Bromo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of tert-butyl 2-(2-broMoethyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 334.2±15.0 °C(Predicted)
• PKA: -1.76±0.40(Predicted)
• PSA: 29.54000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 3.49890

Purity/Quality:

99% ，98% ^*data from raw suppliers

tert-Butyl 2-(2-bromoethyl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2-(2-broMoethyl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 2-(2-broMoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate (118811-03-3) → t-butyl 2-(2-bromoethyl)piperidine-1-carboxylate (210564-52-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.12.042

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) → t-butyl 2-(2-bromoethyl)piperidine-1-carboxylate (210564-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With carbon tetrabromide; sodium carbonate; triphenylphosphine; In dichloromethane; water;

DOI:10.1016/j.ejmech.2016.12.042

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → t-butyl 2-(2-bromoethyl)piperidine-1-carboxylate (210564-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

2: triphenylphosphine; carbon tetrabromide / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With carbon tetrabromide; sodium carbonate; triphenylphosphine; In dichloromethane; water;

DOI:10.1016/j.ejmech.2016.12.042

upstream raw materials:

tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

2(RS)-(2-hydroxyethyl)piperidine

di-tert-butyl dicarbonate

Downstream raw materials:

2-{2-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

thioridazine

2-chloro-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

9-(2-(1-methylpiperidin-2-yl)ethyl)-9H-carbazole

Refernces

• 1、 Scalacci, Nicolò,Brown, Alistair K.,Pavan, Fernando R.,Ribeiro, Camila M.,Manetti, Fabrizio,Bhakta, Sanjib,Maitra, Arundhati,Smith, Darren L.,Petricci, Elena,Castagnolo, Daniele. "Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis". . p. 147 - 158. Retrieved 2016/12/30.