(4-(cyclopentylaMino)-2-(Methylthio)pyriMidin-5-yl)Methanol

Base Information

• Chemical Name: (4-(cyclopentylaMino)-2-(Methylthio)pyriMidin-5-yl)Methanol
• CAS No.: 211245-63-5
• Molecular Formula: C11H17N3OS
• Molecular Weight: 239.341
• Hs Code.: 2933599090
• Mol file: 211245-63-5.mol

Synonyms:(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol;

Chemical Property of (4-(cyclopentylaMino)-2-(Methylthio)pyriMidin-5-yl)Methanol

Chemical Property:

• Boiling Point: 455.7±35.0 °C(Predicted)
• PKA: 13.14±0.10(Predicted)
• PSA: 86.57000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 1.46720

Purity/Quality:

98% HPLC ^*data from raw suppliers

(4-(Cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-(cyclopentylaMino)-2-(Methylthio)pyriMidin-5-yl)Methanol

There total 4 articles about (4-(cyclopentylaMino)-2-(Methylthio)pyriMidin-5-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester (211245-62-4) → [4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-yl]methanol (211245-63-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 12 - 20 ℃; for 4h;

Reference yield: 90.0%

→ [4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-yl]methanol (211245-63-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - 20 ℃; for 5h; Inert atmosphere;

Reference yield:

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester (5909-24-0) → [4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-yl]methanol (211245-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / triethylamine / tetrahydrofuran / 14 h

2: 86 percent / LAH / tetrahydrofuran / 6 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm049355+

upstream raw materials:

4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Cyclopentamine

Downstream raw materials:

trans-2-hydroxycyclopentylamine

6-bromo-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

PD 0332991

6?bromo?8?cyclopentyl?5?methyl?2?(methylsulfinyl)pyrido[2,3?d]pyrimidin?7(8H)?one