2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro-

Base Information

• Chemical Name: 2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro-
• CAS No.: 212554-45-5
• Molecular Formula: C15H10ClNO
• Molecular Weight: 255.703
• DSSTox Substance ID: DTXSID50372901
• Mol file: 212554-45-5.mol

Synonyms:212554-45-5;2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro-;DTXSID50372901

Chemical Property of 2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro-

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 255.0450916
• Heavy Atom Count: 18
• Complexity: 366

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=C2C3=CC=CC=C3NC2=O)Cl

Technology Process of 2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro-

There total 1 articles about 2H-Indol-2-one, 3-[(2-chlorophenyl)methylene]-1,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-oxoindole (59-48-3) + 2-chloro-benzaldehyde (89-98-5) → 3-(2'-chloro)-benzylidene-1,3-dihydro-indol-2-one (212554-45-5)

Guidance literature:

With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate; at 80 ℃; for 1h;

DOI:10.1515/HC.2008.14.4.263

Reference yield: 89.0%

3-(2'-chloro)-benzylidene-1,3-dihydro-indol-2-one (212554-45-5) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → dimethyl ((3SR,4'SR)-4'-(2-chlorophenyl)-2-oxo-2',4'-dihydrospiro[indoline-3,3'-pyrazol]-5'-yl)phosphonate

Guidance literature:

With methanol; potassium hydroxide; at 25 ℃; for 1.5h; diastereoselective reaction;

DOI:10.1039/c5ob01382h

Reference yield: 85.0%

1H-indene-1,3(2H)-dione (606-23-5) + ethanol (64-17-5) + 3-(2'-chloro)-benzylidene-1,3-dihydro-indol-2-one (212554-45-5) → ethyl (2-(6-(2-chlorophenyl)-7,12-dioxo-7,12-dihydroindeno[1,2-a]fluoren-5-yl)phenyl)carbamate

Guidance literature:

With triethylamine; for 24h; Reflux;

DOI:10.1039/c9ob01779h

upstream raw materials:

2-oxoindole

2-chloro-benzaldehyde

Downstream raw materials:

3-(2-chlorobenzyl)-1,3-dihydroindol-2-one

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