4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

Base Information

Chemical Name:4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
CAS No.:212578-38-6
Molecular Formula:C10H11NO3
Molecular Weight:193.19900
Hs Code.:2934999090
DSSTox Substance ID:DTXSID90445683
Mol file:212578-38-6.mol

Synonyms:212578-38-6;4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid;4-METHYL-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-2-CARBOXYLIC ACID;4-methyl-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid;SCHEMBL925260;DTXSID90445683;SSVIRLKDUUXSTR-UHFFFAOYSA-N;MFCD11506351;AKOS006281231;MS-22662;CS-0333629;FT-0723253;W-206612;3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxylic acid;3,4-Dihydro-4-methyl-2H-1,4-benzoxazole-2-carboxylic acid;4-methyl-3,4-dihydro-2h-benzo[1,4]oxazine-2-carboxylic acid;4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid, AldrichCPR;4-METHYL-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-2-CARBOXYLICACID

Suppliers and Price of 4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylicAcid
100mg
$ 90.00

SynQuest Laboratories
3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxylic acid 97%
1 g
$ 324.00

SynQuest Laboratories
3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-2-carboxylic acid 97%
250 mg
$ 135.00

ChemBridge Corporation
4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylicacid 95%
250 mg
$ 99.00

American Custom Chemicals Corporation
METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 95.00%
1G
$ 803.07

American Custom Chemicals Corporation
METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 95.00%
250MG
$ 676.46

Total 7 raw suppliers

Chemical Property of 4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:376.346oC at 760 mmHg
Flash Point:181.408oC
PSA：49.77000
Density:1.283g/cm3
LogP:1.03340
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:193.07389321
Heavy Atom Count:14
Complexity:231

Purity/Quality:

97% ^*data from raw suppliers

4-methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CC(OC2=CC=CC=C21)C(=O)O

Technology Process of 4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

There total 5 articles about 4-Methyl-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 54442-28-3
ethyl 4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate

: 212578-38-6
4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1021/jm021050c

Reference yield:

: 22244-22-0
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate

: 212578-38-6
4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / K₂CO₃ / acetone / 18 h / Heating

2: 93 percent / aq. KOH / methanol; tetrahydrofuran / 1 h / 20 °C

With potassium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm021050c

Reference yield:

: 95-55-6
2-amino-phenol

: 212578-38-6
4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / K₂CO₃ / acetone / 20 h / Heating

2: 67 percent / K₂CO₃ / acetone / 18 h / Heating

3: 93 percent / aq. KOH / methanol; tetrahydrofuran / 1 h / 20 °C

With potassium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm021050c