2-(2-Carboxy-Ethyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester

Base Information

• Chemical Name: 2-(2-Carboxy-Ethyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester
• CAS No.: 212650-48-1
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.29900
• Mol file: 212650-48-1.mol

Synonyms:

Chemical Property of 2-(2-Carboxy-Ethyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester

Chemical Property:

• PSA: 66.84000
• LogP: 2.18860

Purity/Quality:

98.5% ^*data from raw suppliers

3-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Carboxy-Ethyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester

There total 18 articles about 2-(2-Carboxy-Ethyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2-carboxy-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (741269-02-3) → 3-[1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]propanoic acid (65595-02-0,212650-48-1)

Guidance literature:

With hydrogen; palladium on activated carbon; In ethanol; for 24h;

Reference yield: 90.0%

(2S)-N-t-butoxycarbonyl-2-(3’-methoxy-3’-oxo-1-propyl)pyrrolidine (179685-62-2) → 3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]propanoic acid (65595-02-0,212650-48-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.tetlet.2004.02.052

Reference yield: 74.0%

(E)-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]-2-propenoic acid (179040-15-4) → 3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]propanoic acid (65595-02-0,212650-48-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h; under 2327.17 Torr;

DOI:10.1139/v00-066

upstream raw materials:

2-(2-carboxy-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

1-(tert-butoxycarbonyl)-L-proline

acrylic acid

cycl-isopropylidene malonate

Downstream raw materials:

(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

(E)-ethyl 2-((S)-tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-oxo-3-phenylpropanoate

Refernces

• 1、 Mudhar, Harminder,Witty, Andrew. "One-pot conversion of alkyl aldehydes into substituted propanoic acids via Knoevenagel condensation with Meldrum's acid". experimental part. p. 4972 - 4974. Retrieved 2011/01/12.
• 2、 -. "TRICYCLIC COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE". Page/Page column 41-42. . Retrieved 2010/02/14.