Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)-

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)-
CAS No.:213250-59-0
Molecular Formula:C21H42O5Si2
Molecular Weight:430.732
Hs Code.:
Mol file:213250-59-0.mol

Synonyms:

Suppliers and Price of Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)-

There total 13 articles about Cyclohexanecarboxylic acid, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-methylene-, methyl ester, (3R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 852380-64-4
(3R,5R)-5-[(tert-butyldimethylsilyl)oxy]-1,3-dihydroxy-4-methylene-cyclohexanecarboxylic acid methyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 213250-59-0
methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b01295

Reference yield: 25.0%

: 19493-09-5
Methylenetriphenylphosphorane

: 213250-58-9
(3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-oxocyclohexanecarboxylic acid methyl ester

: 213250-59-0
methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate

Guidance literature:: Inert atmosphere;
DOI:10.1002/ejoc.201201261

Reference yield: 24.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 213250-58-9
(3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-oxocyclohexanecarboxylic acid methyl ester

: 213250-59-0
methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexanes; at 0 - 20 ℃; for 0.833333h;

(3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-oxocyclohexanecarboxylic acid methyl ester; In tetrahydrofuran; hexanes; at 0 - 20 ℃; for 4.33333h;