Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)-

Base Information

Chemical Name:Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)-
CAS No.:213668-31-6
Molecular Formula:C16H21BrN2O2
Molecular Weight:353.259
Hs Code.:
Mol file:213668-31-6.mol

Synonyms:(2S,5R)-2-(4-Bromo-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine;

Suppliers and Price of Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)-

Chemical Property:

Melting Point:54 - 55 °C
PSA：43.18000
LogP:2.35940

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)-

There total 2 articles about Pyrazine, 2-[(4-bromophenyl)methyl]-2,5-dihydro-3,6-dimethoxy-5-(1-methylethyl)- , (2S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 589-15-1
1-bromomethyl-4-bromobenzene

: 213668-31-6
(2S,5R)-2-(4-bromobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: (2R,5R)-2-(4-Bromo-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1081/SCC-200048407

Reference yield: 90.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 589-15-1
1-bromomethyl-4-bromobenzene

: 213668-31-6
(2S,5R)-2-(4-bromobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; hexane; at -78 ℃; for 3h; optical yield given as %de; diastereoselective reaction;
DOI:10.1111/j.1751-1097.2008.00304.x

Reference yield: 62.0%

: 77123-57-0
4-[(trimethylsilyl)ethynyl]bezaldehyde

: 213668-31-6
(2S,5R)-2-(4-bromobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 1241959-19-2
(4-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)methyl)phenyl)(4-((trimethylsilyl)ethynyl)phenyl)methanol

Guidance literature:: (2S,5R)-2-(4-bromobenzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.25h;

4-[(trimethylsilyl)ethynyl]bezaldehyde; In tetrahydrofuran; pentane; at -78 ℃;
DOI:10.1002/chem.201000441