Technology Process of 2-Buten-1-ol,
2-methyl-4-[(1R,4S,5R)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-5-[(3E)-
3-methyl-5-(phenylsulfonyl)-3-pentenyl]-2-cyclopenten-1-yl]-, (2E)-
There total 35 articles about 2-Buten-1-ol,
2-methyl-4-[(1R,4S,5R)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-5-[(3E)-
3-methyl-5-(phenylsulfonyl)-3-pentenyl]-2-cyclopenten-1-yl]-, (2E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 80 percent / N-bromosuccinimide; (C6H5)3P / CH2Cl2 / 2 h / 0 °C
2: (n-C4H9)Li / tetrahydrofuran; hexane / 0.67 h / -30 °C
3: 524 mg / Na; NH3 / tetrahydrofuran / 1 h / -78 °C
4: pyridinium dichromate; molecular sieves 4A / CH2Cl2 / 5 h / 20 °C
5: 3.70 g / C6H5Li / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / 0 °C
6: 85 percent / pyridinium chlorochromate; Al2O3 / benzene / 5 h / 40 °C
7: di(isobutyl)aluminum hydride / toluene; hexane / 0.17 h / -78 °C
8: 80 percent / NaH / tetrahydrofuran / 1 h / 0 °C
9: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 20 °C
10: 92 percent / (n-C4H9)3P; pyridine / 2 h / 60 °C
11: 90 percent / Oxone(R) / tetrahydrofuran; methanol; H2O / 3 h / 20 °C
12: 98 percent / di(isobutyl)aluminum hydride / toluene; hexane / 0.25 h / -78 °C
With
pyridine; aluminum oxide; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; oxone; diisobutylaluminum hydride; tributylphosphine; 4 A molecular sieve; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; phenyllithium; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; toluene; benzene;
DOI:10.1016/S0040-4020(02)01474-6
- Guidance literature:
-
Multi-step reaction with 11 steps
1: (n-C4H9)Li / tetrahydrofuran; hexane / 0.67 h / -30 °C
2: 524 mg / Na; NH3 / tetrahydrofuran / 1 h / -78 °C
3: pyridinium dichromate; molecular sieves 4A / CH2Cl2 / 5 h / 20 °C
4: 3.70 g / C6H5Li / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / 0 °C
5: 85 percent / pyridinium chlorochromate; Al2O3 / benzene / 5 h / 40 °C
6: di(isobutyl)aluminum hydride / toluene; hexane / 0.17 h / -78 °C
7: 80 percent / NaH / tetrahydrofuran / 1 h / 0 °C
8: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 20 °C
9: 92 percent / (n-C4H9)3P; pyridine / 2 h / 60 °C
10: 90 percent / Oxone(R) / tetrahydrofuran; methanol; H2O / 3 h / 20 °C
11: 98 percent / di(isobutyl)aluminum hydride / toluene; hexane / 0.25 h / -78 °C
With
pyridine; aluminum oxide; dipyridinium dichromate; n-butyllithium; oxone; diisobutylaluminum hydride; tributylphosphine; 4 A molecular sieve; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; phenyllithium; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; toluene; benzene;
DOI:10.1016/S0040-4020(02)01474-6
![(E)-4-[(1R,4S,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-1-methyl-4-(2-methyl-[1,3]dioxolan-2-yl)-cyclopent-2-enyl]-2-methyl-but-2-enoic acid ethyl ester](/Databaselist/images/loading.webp)
