2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane

Base Information

• Chemical Name: 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane
• CAS No.: 1026459-62-0
• Molecular Formula: C₂₇H₃₇ClO₄S
• Molecular Weight: 493.107

Synonyms:

Chemical Property of 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane

There total 36 articles about 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-[(1R,4S,5R)-5-((E)-5-benzenesulfonyl-3-methyl-3-pentenyl)-1-methyl-4-(2-methyl[1,3]dioxolan-2-yl)-2-cyclopentenyl]-2-methyl-2-buten-1-ol (213817-00-6) → 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane (1026459-62-0)

Guidance literature:

With dmap; methanesulfonyl chloride; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(02)01474-6

Reference yield:

(S,E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropionic acid ethyl ester (81997-76-4) → 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane (1026459-62-0)

Guidance literature:

Multi-step reaction with 34 steps

1: 69 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -78 °C

2: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

3: 100 percent / imidazole / dimethylformamide / 10 h / 20 °C

4: 99 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

5: 94 percent / NaH / dimethylformamide / 12 h / 20 °C

6: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7: 99 percent / pyridine / 10 h / 20 °C

8: 80 percent / CH₃COOH / H₂O / 12 h / 65 °C

9: NaIO₄; (NH₄)2SO₄ / methanol; H₂O / 0.25 h / 0 °C

10: 13 g / NaBH₄ / methanol; H₂O / 0.08 h / 0 °C

11: 96 percent / imidazole / dimethylformamide / 5 h / 20 °C

12: 100 percent / K₂CO₃ / methanol / 2 h / 20 °C

13: 90 percent / pyridinium chlorochromate; molecular sieves 4 Amgstroem / CH₂Cl₂ / 2 h / 20 °C

14: 86 percent / NaH; 15-crown-5 / toluene / 1 h / 20 °C

15: 97 percent / CH₃COOH / H₂O / 5 h / 20 °C

16: 100 percent / pyridine / 5 h / 20 °C

17: 90 percent / trimethylsilyl triflate / CH₂Cl₂ / 18 h / -40 °C

18: 98 percent / NaBH₄ / methanol / 0.25 h / 0 °C

19: 93 percent / N-phenylthiosuccinimide; (n-C₄H₉)3P; pyridine / 6 h / 20 °C

20: 100 percent / K₂CO₃ / methanol / 3 h / 20 °C

21: (n-C₄H₉)3P; pyridine / 5 h / 60 °C

22: 16.8 g / Oxone(R) / tetrahydrofuran; methanol; H₂O / 3 h / 20 °C

23: (n-C₄H₉)Li / tetrahydrofuran; hexane / 0.67 h / -30 °C

24: 524 mg / Na; NH₃ / tetrahydrofuran / 1 h / -78 °C

25: pyridinium dichromate; molecular sieves 4A / CH₂Cl₂ / 5 h / 20 °C

26: 3.70 g / C₆H₅Li / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / 0 °C

27: 85 percent / pyridinium chlorochromate; Al₂O₃ / benzene / 5 h / 40 °C

28: di(isobutyl)aluminum hydride / toluene; hexane / 0.17 h / -78 °C

29: 80 percent / NaH / tetrahydrofuran / 1 h / 0 °C

30: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

31: 92 percent / (n-C₄H₉)3P; pyridine / 2 h / 60 °C

32: 90 percent / Oxone(R) / tetrahydrofuran; methanol; H₂O / 3 h / 20 °C

33: 98 percent / di(isobutyl)aluminum hydride / toluene; hexane / 0.25 h / -78 °C

34: methanesulfonyl chloride; 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; 1H-imidazole; dmap; aluminum oxide; ammonium sulfate; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; oxone; diisobutylaluminum hydride; N-(phenylthio)succinimide; 15-crown-5; tributylphosphine; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; potassium carbonate; acetic acid; methanesulfonyl chloride; phenyllithium; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/S0040-4020(02)01474-6

Reference yield:

(2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-2-buten-1-ol (162188-27-4) → 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane (1026459-62-0)

Guidance literature:

Multi-step reaction with 13 steps

1: 80 percent / N-bromosuccinimide; (C₆H₅)3P / CH₂Cl₂ / 2 h / 0 °C

2: (n-C₄H₉)Li / tetrahydrofuran; hexane / 0.67 h / -30 °C

3: 524 mg / Na; NH₃ / tetrahydrofuran / 1 h / -78 °C

4: pyridinium dichromate; molecular sieves 4A / CH₂Cl₂ / 5 h / 20 °C

5: 3.70 g / C₆H₅Li / tetrahydrofuran; cyclohexane; diethyl ether / 0.25 h / 0 °C

6: 85 percent / pyridinium chlorochromate; Al₂O₃ / benzene / 5 h / 40 °C

7: di(isobutyl)aluminum hydride / toluene; hexane / 0.17 h / -78 °C

8: 80 percent / NaH / tetrahydrofuran / 1 h / 0 °C

9: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

10: 92 percent / (n-C₄H₉)3P; pyridine / 2 h / 60 °C

11: 90 percent / Oxone(R) / tetrahydrofuran; methanol; H₂O / 3 h / 20 °C

12: 98 percent / di(isobutyl)aluminum hydride / toluene; hexane / 0.25 h / -78 °C

13: methanesulfonyl chloride; 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; dmap; aluminum oxide; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; oxone; diisobutylaluminum hydride; tributylphosphine; 4 A molecular sieve; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; methanesulfonyl chloride; phenyllithium; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; water; toluene; benzene;

DOI:10.1016/S0040-4020(02)01474-6

upstream raw materials:

(E)-4-[(1R,4S,5R)-5-((E)-5-benzenesulfonyl-3-methyl-3-pentenyl)-1-methyl-4-(2-methyl[1,3]dioxolan-2-yl)-2-cyclopentenyl]-2-methyl-2-buten-1-ol

(S,E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropionic acid ethyl ester

(2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-2-buten-1-ol

(E)-[(4-bromo-3-methylbut-2-en-1-yl)oxy](tert-butyl)dimethylsilane

Downstream raw materials:

palominol

2-((1S,3aR,12aR)-(5E,9E)-8-benzenesulfonyl-3a,6,10-trimethyl-1,3a,4,7,8,11,12,12a-octahydrocyclopenta[a]cycloundecen-1-yl)-2-methyl[1,3]dioxolane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1026459-62-0 2-[(1S,4R,5R)-5-((E)-5-Benzenesulfonyl-3-methyl-pent-3-enyl)-4-((E)-4-chloro-3-methyl-but-2-enyl)-4-methyl-cyclopent-2-enyl]-2-methyl-[1,3]dioxolane

Send

Send

Metric Ton KG G Pound L ML

Send

Send