1,3,8-Triazaspiro[4.5]decan-4-one, 3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)- 1,3-dioxolan-2-yl]propyl]-1-phenyl-

Base Information

Chemical Name:1,3,8-Triazaspiro[4.5]decan-4-one, 3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)- 1,3-dioxolan-2-yl]propyl]-1-phenyl-
CAS No.:214461-01-5
Molecular Formula:C41H47FN4O4
Molecular Weight:678.847
Hs Code.:

1,3,8-Triazaspiro[4.5]decan-4-one,
3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)-
1,3-dioxolan-2-yl]propyl]-1-phenyl-

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Chemical Property of 1,3,8-Triazaspiro[4.5]decan-4-one, 3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)- 1,3-dioxolan-2-yl]propyl]-1-phenyl-

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Technology Process of 1,3,8-Triazaspiro[4.5]decan-4-one, 3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)- 1,3-dioxolan-2-yl]propyl]-1-phenyl-

There total 4 articles about 1,3,8-Triazaspiro[4.5]decan-4-one, 3-[2-[(6-acetyl-2-naphthalenyl)ethylamino]ethyl]-8-[3-[2-(4-fluorophenyl)- 1,3-dioxolan-2-yl]propyl]-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 54080-21-6
8-<3-<2-(4-fluorophenyl)-1,3-dioxolan-2-yl>propyl>-1-phenyl-1,3,8-triazaspiro<4.5>decan-4-one

: 214460-99-8
6-acetyl-2-(ethyl-2-[(4-methylphenyl)-sulfonyloxy]-ethylamino)-naphthalene

: 1-[6-(ethyl-2-[(8-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl}-4-phenyl-2,4,8-triazaspiro[4.5]dec-1-en-1-yl)-oxy]-ethylamino)-2-naphthyl]-1-ethanone

: 214461-01-5
1-[6-(ethyl-2-[(8-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl}-1-oxo-4-phenyl-2,4,8-triazaspiro[4.5]dec-2-yl)]-ethylamino)-2-naphthyl]-1-ethanone

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In water; toluene; at 90 ℃; for 1h;
DOI:10.1007/PL00013476

Reference yield:

: 3900-45-6
6-methoxy-2-acetylnaphthalene

: 214461-01-5
1-[6-(ethyl-2-[(8-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl}-1-oxo-4-phenyl-2,4,8-triazaspiro[4.5]dec-2-yl)]-ethylamino)-2-naphthyl]-1-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / aq. HCl / CH₂Cl₂ / 2 h / Heating

2: 12 percent / NaHSO₄ / H₂O / 72 h / 130 - 140 °C

3: 30 percent / pyridine / 48 h / Ambient temperature

4: 56 percent / NaOH, Bu₄NHSO₄ / H₂O; toluene / 1 h / 90 °C

With hydrogenchloride; sodium hydroxide; sodium hydrogen sulfate; tetra(n-butyl)ammonium hydrogensulfate; In pyridine; dichloromethane; water; toluene;
DOI:10.1007/PL00013476

Reference yield:

: 10441-41-5
1-(6-hydroxy-2-naphthyl)ethan-1-one

: 214461-01-5
1-[6-(ethyl-2-[(8-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-propyl}-1-oxo-4-phenyl-2,4,8-triazaspiro[4.5]dec-2-yl)]-ethylamino)-2-naphthyl]-1-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 12 percent / NaHSO₄ / H₂O / 72 h / 130 - 140 °C

2: 30 percent / pyridine / 48 h / Ambient temperature

3: 56 percent / NaOH, Bu₄NHSO₄ / H₂O; toluene / 1 h / 90 °C

With sodium hydroxide; sodium hydrogen sulfate; tetra(n-butyl)ammonium hydrogensulfate; In pyridine; water; toluene;
DOI:10.1007/PL00013476