Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate

Base Information

• Chemical Name: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate
• CAS No.: 214470-57-2
• Molecular Formula: C12H14ClNO6
• Molecular Weight: 303.699
• Mol file: 214470-57-2.mol

Synonyms:methyl 4-(3-chloropropoxy)-3-methoxy-2-nitrobenzoate;methyl 2-nitro-5-methoxy-4-(3-chloropropoxy)benzoate;4-(3-chloropropoxy)-5-methoxy-2-nitro-benzoic acid methyl ester;4-(3-chloro-propoxy)-5-methoxy-2-nitro-benzoic acid methyl ester;

Chemical Property of Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate

Chemical Property:

• Melting Point: 64 - 66 °C
• Boiling Point: 457.3±40.0 °C(Predicted)
• PSA: 90.58000
• Density: 1.311±0.06 g/cm3(Predicted)
• LogP: 2.92090
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate

There total 5 articles about Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.98%

methyl 4-(3-chloropropoxy)-3-methoxybenzoate (111627-40-8) → methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate (214470-57-2)

Guidance literature:

With nitric acid; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bioorg.2019.103328

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate (214470-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetrabutylammonium iodide / acetone / 2 h / Heating

2: acetic acid; nitric acid / 3 h / 20 - 50 °C

With nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; In acetone;

DOI:10.3390/11040286

Reference yield:

3-methoxy-4-hydroxybenzoic acid (121-34-6) → methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate (214470-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 48 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

3: acetic acid; acetic anhydride; nitric acid / 6 h / 20 °C

With sulfuric acid; nitric acid; acetic anhydride; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-(3-chloropropoxy)-3-methoxybenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

3-hydroxy-4-methoxybenzoate

1-iodo-3-chloro-propane

Downstream raw materials:

methyl 5-methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzoate

UNC0642