3-Amino-8-fluorochromane-5-carboxamide

Base Information

Chemical Name:3-Amino-8-fluorochromane-5-carboxamide
CAS No.:214823-09-3
Molecular Formula:C10H11FN2O2
Molecular Weight:210.208
Hs Code.:
DSSTox Substance ID:DTXSID20474345
Mol file:214823-09-3.mol

Synonyms:3-amino-8-fluorochromane-5-carboxamide;214823-09-3;SCHEMBL5759640;DTXSID20474345;CQZHUEJNSOTLNG-UHFFFAOYSA-N;3-amino-8-fluorochromane-5 carboxamide;3-Amino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide

Suppliers and Price of 3-Amino-8-fluorochromane-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Amino-8-fluorochromane-5-carboxamide

Chemical Property:

PSA：79.33000
LogP:1.77130
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:210.08045576
Heavy Atom Count:15
Complexity:262

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(COC2=C(C=CC(=C21)C(=O)N)F)N

Technology Process of 3-Amino-8-fluorochromane-5-carboxamide

There total 1 articles about 3-Amino-8-fluorochromane-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214822-96-5
4-Fluoro-3-hydroxy-benzoic acid methyl ester

: 214823-09-3
3-amino-8-fluorochromane-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: K₂CO₃ / acetone

2.1: N,N-diethylaniline

3.1: aq. NaOH / ethanol

4.1: CDI / tetrahydrofuran

4.2: NH₃(gas) / tetrahydrofuran

5.1: 60 percent / potassium nitrite; iodine; 18-crown-6 / pyridine / tetrahydrofuran / 20 °C / sonication

6.1: 97 percent / NaBH₄; SiO₂ / CHCl₃; propan-2-ol / 0.5 h / 20 °C

7.1: 61 percent / hydrazine hydrate / Raney Ni / ethanol; tetrahydrofuran / 1 h / 45 °C

With sodium hydroxide; sodium tetrahydroborate; potassium nitrite; 18-crown-6 ether; iodine; silica gel; potassium carbonate; hydrazine hydrate; 1,1'-carbonyldiimidazole; N,N-diethylaniline; pyridine; nickel; In tetrahydrofuran; ethanol; chloroform; isopropyl alcohol; acetone;
DOI:10.1021/jm060218h

Reference yield: 100.0%

: 214823-09-3
3-amino-8-fluorochromane-5-carboxamide

: 843652-88-0
3-chloro-1-[5-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one

: 843652-89-1
8-fluoro-3-({3-[5-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl]-3-oxopropyl}amino)chromane-5-carboxamide

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 214823-09-3
3-amino-8-fluorochromane-5-carboxamide

: 843653-25-8
3-{cyclobutyl[3-(5-fluoro-1H-indol-3-yl)propyl]amino}-8-fluorochromane-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / triethylamine / dimethylsulfoxide / 9.5 h / 90 °C

2: 78 percent / sodium cyanoborohydride; acetic acid / methanol / 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dimethyl sulfoxide;
DOI:10.1021/jm060218h