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214822-96-5

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214822-96-5 Usage

General Description

METHYL 4-FLUORO-3-HYDROXYBENZOATE is a chemical compound with the molecular formula C8H7FO3. It is an ester derived from methyl alcohol and 4-fluoro-3-hydroxybenzoic acid. METHYL 4-FLUORO-3-HYDROXYBENZOATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the field of medicine and agriculture due to its structural properties. METHYL 4-FLUORO-3-HYDROXYBENZOATE is also used as a flavoring agent and in the production of fragrances. However, it is important to handle this chemical with care as it may pose health and environmental risks if not properly managed.

Check Digit Verification of cas no

The CAS Registry Mumber 214822-96-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,8,2 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214822-96:
(8*2)+(7*1)+(6*4)+(5*8)+(4*2)+(3*2)+(2*9)+(1*6)=125
125 % 10 = 5
So 214822-96-5 is a valid CAS Registry Number.

214822-96-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name METHYL 4-FLUORO-3-HYDROXYBENZOATE

1.2 Other means of identification

Product number -
Other names 4-Fluoro-3-hydroxy-benzoic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:214822-96-5 SDS

214822-96-5Relevant articles and documents

Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes

Wright, Jay S.,Sharninghausen, Liam S.,Preshlock, Sean,Brooks, Allen F.,Sanford, Melanie S.,Scott, Peter J. H.

supporting information, p. 6915 - 6921 (2021/05/29)

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp2)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [18F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FXFN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative. The products, [18F]1-fluoro-3,5-dimethoxybenzene and an 18F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochemical yield and >99% radiochemical purity and 25% isolated radiochemical yield and 99% radiochemical purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (Am), respectively.

NOVEL INHIBITORS OF MAP4K1

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Page/Page column 63; 64, (2018/12/13)

The invention relates to novel inhibitors of MAP4K1 (HPK1) useful for the treatment of diseases or disorders characterised by dysregulation of the signal transduction pathways associated with MAPK activation, including hyperproliferative diseases, diseases of immune system dysfunction, inflammatory disorders, neurological diseases, and cardiovascular diseases. The invention further relates to pharmaceutical compositions comprising the same and methods of treatment of said diseases and disorders. The inhibitors are of formula (I) wherein the definitions for A, D, E, F, R5, R6, R7, Z, ring Q, n, x and y are as given in the application.

HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

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Paragraph 0903, (2018/06/12)

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

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