4-(3-methyloxiran-2-yl)benzonitrile

Base Information

• Chemical Name: 4-(3-methyloxiran-2-yl)benzonitrile
• CAS No.: 104953-00-6
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.188
• Mol file: 104953-00-6.mol

Synonyms:

Chemical Property of 4-(3-methyloxiran-2-yl)benzonitrile

Chemical Property:

• Vapor Pressure: 0.00258mmHg at 25°C
• Boiling Point: 286.8°Cat760mmHg
• Flash Point: 120.6°C
• PSA: 36.32000
• Density: 1.15g/cm³
• LogP: 2.01808

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-methyloxiran-2-yl)benzonitrile

There total 4 articles about 4-(3-methyloxiran-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-cyanophenyl methyl ketone (1443-80-7) + trimethylsulphonium iodide (2181-42-2) → p-cyano-α-methylstyrene oxide (104953-00-6)

Guidance literature:

trimethylsulphonium iodide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

4-cyanophenyl methyl ketone; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja400325w

Reference yield: 77.0%

4-cyanophenyl methyl ketone (1443-80-7) + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → p-cyano-α-methylstyrene oxide (104953-00-6)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 12.5h;

DOI:10.1021/jo982101+

Reference yield: 74.0%

4-cyanophenyl methyl ketone (1443-80-7) + trimethylsulfoxonium iodide (1774-47-6) → p-cyano-α-methylstyrene oxide (104953-00-6)

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h;

4-cyanophenyl methyl ketone; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 16h;

upstream raw materials:

4-cyanophenyl methyl ketone

dimethylsulfoxonium methylide

trimethylsulphonium iodide

trimethylsulfoxonium iodide

Downstream raw materials:

4-cyanophenyl methyl ketone

4-((S)-1,2-Dihydroxy-1-methyl-ethyl)-benzonitrile