N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine

Base Information

• Chemical Name: N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine
• CAS No.: 215592-20-4
• Molecular Formula: C22H21Cl2N5
• Molecular Weight: 426.34200
• Mol file: 215592-20-4.mol

Synonyms:N-(7-Chloro-quinolin-4-yl)-N'-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-ethane-1,2-diamine;7-chloro-N-{2-[(7-chloroquinolin-4-yl-)amino]ethyl}quinolin-4-amine;N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-1,2-ethanediamine;

Chemical Property of N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine

Chemical Property:

• Boiling Point: 676.6±55.0 °C(Predicted)
• PKA: 8.85±0.19(Predicted)
• PSA: 61.87000
• Density: 1.376±0.06 g/cm3(Predicted)
• LogP: 5.74030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine shows anti-malarial activity due to its bis(quinoline) structure. In addition,

Technology Process of N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine

There total 2 articles about N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → N1-(7-chloroquinolin-4-yl)-N2-(2-((7chloroquinolin-4-yl)amino)ethyl)ethane-1,2-diamine (215592-20-4)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2012.07.037

Reference yield: 56.1%

C27H29Cl2N5O2 → N1-(7-chloroquinolin-4-yl)-N2-(2-((7chloroquinolin-4-yl)amino)ethyl)ethane-1,2-diamine (215592-20-4)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.8b00222

upstream raw materials:

4,7-dichloroquinoline

3-azapentane-1,5-diamine