4-Isoxazolecarboxylic acid, 4,5-dihydro-5-(hydroxymethyl)-3-(4-methoxyphenyl)-, ethyl ester, (4R,5R)-

Base Information

Chemical Name:4-Isoxazolecarboxylic acid, 4,5-dihydro-5-(hydroxymethyl)-3-(4-methoxyphenyl)-, ethyl ester, (4R,5R)-
CAS No.:216063-12-6
Molecular Formula:C₁₄H₁₇NO₅
Molecular Weight:279.293
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Isoxazolecarboxylic acid, 4,5-dihydro-5-(hydroxymethyl)-3-(4-methoxyphenyl)-, ethyl ester, (4R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-Isoxazolecarboxylic acid, 4,5-dihydro-5-(hydroxymethyl)-3-(4-methoxyphenyl)-, ethyl ester, (4R,5R)-

There total 2 articles about 4-Isoxazolecarboxylic acid, 4,5-dihydro-5-(hydroxymethyl)-3-(4-methoxyphenyl)-, ethyl ester, (4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 10080-68-9
(E)-ethyl 4-hydroxybut-2-enoate

: 216063-12-6
(4R,5R)-5-Hydroxymethyl-3-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

: (4R,5S)-5-Hydroxymethyl-3-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: With tert-butylhypochlorite; L-(+)-diisopropyl tartrate; diisopropyl zinc; In 1,4-dioxane; hexane; chloroform; at 25 ℃; for 15h; Title compound not separated from byproducts;
DOI:10.1246/cl.2002.1112

Reference yield:

: 10080-68-9
(E)-ethyl 4-hydroxybut-2-enoate

: 38435-51-7
N-hydroxy-4-methoxy-benzenecarboximidoyl chloride

: (4S,5R)-5-Hydroxymethyl-3-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

: 216063-12-6
(4R,5R)-5-Hydroxymethyl-3-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: With L-(+)-diisopropyl tartrate; diethylzinc; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 25 deg C, CHCl₃, 1,4-dioxane;
DOI:10.1246/cl.1998.1023

Reference yield:

: 216063-12-6
(4R,5R)-5-Hydroxymethyl-3-(4-methoxy-phenyl)-4,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

: 3-(4-methoxy-phenyl)-6,6a-dihydro-3aH-furo[3,4-d]isoxazol-4-one

: 3-(4-methoxy-phenyl)-6,6a-dihydro-3aH-furo[3,4-d]isoxazol-4-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 1h; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1246/cl.1998.1023